Results 31 to 40 of about 10,818 (180)
N 1-methyladenosine (m1A) RNA modification: the key to ribosome control [PDF]
The Journal of Biochemistry, 2020 AbstractRNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply ...
Kazuhiko Igarashi, Hiroki Shima
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Journal of Inflammation Research, 2023 Haishi Zheng,1,2 Yirixiati Aihaiti,2 Yongsong Cai,2 Qiling Yuan,2 Mingyi Yang,2 Zheng Li,2 Ke Xu,2 Peng Xu1,2 1Department of Orthopedics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Department of Joint ...
Zheng H +7 more
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m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Cell Reports, 2022 N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Sung Ho Boo, Hongseok Ha, Yoon Ki Kim
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RNA m1A Methyltransferase TRMT6 Predicts Poorer Prognosis and Promotes Malignant Behavior in Glioma
Frontiers in Molecular Biosciences, 2021 Background: Glioma is the most prevalent central nervous system tumor in humans, and its prognosis remains unsatisfactory due to a lack of effective therapeutic targets.
Beibei Wang +3 more
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Frontiers in Immunology, 2022 RNA modification of m6A/m5C/m1A contributes to the occurrence and development of cancer. Consequently, this study aimed to investigate the functions of m6A/m5C/m1A regulated genes in the prognosis and immune microenvironment of hepatocellular carcinoma ...
Dan Li +9 more
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Frontiers in Cell and Developmental Biology, 2021 Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer.
Enhao Wang +7 more
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Frontiers in Immunology, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Meng Mao +8 more
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Effect of M1a and M1b Category in Metastatic Colorectal Cancer [PDF]
The Oncologist, 2014 Abstract Background. In 2009, the American Joint Committee on Cancer version 7 staging system introduced the M1 subclassifications M1a (single metastatic site) and M1b (peritoneal or multiple metastatic sites). The study objectives were to evaluate the prognostic effect of site of metastasis and M1a/b
Hagen, Kennecke +6 more
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m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer
Translational Oncology, 2019 BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao +17 more
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MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
Cancer Medicine, 2022 AbstractBackgroundDistant metastasis is the main cause of mortality in colorectal cancer (CRC) patients. N1‐methyladenosine (m1A) is a type of epitranscriptome modification. While its regulatory effect on mRNA and its role in CRC metastasis remain unclear.MethodsThe m1A methylation profile of mRNAs in CRC was revealed by m1A methylated RNA ...
Meng Xue +6 more
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