Results 61 to 70 of about 10,818 (180)

Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs

Nature Communications, 2019
N 1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5.
Anya V. Grozhik, Anthony O. Olarerin-George, Miriam Sindelar, Xing Li, Steven S. Gross, Samie R. Jaffrey   +5 more
doaj   +1 more source

N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Nature Communications, 2021
Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases ...
Yanying Wang, Jing Wang, Xiaoyu Li, Xushen Xiong, Jianyi Wang, Ziheng Zhou, Xiaoxiao Zhu, Yang Gu, Dan Dominissini, Lei He, Yong Tian, Chengqi Yi, Zusen Fan   +12 more
doaj   +1 more source

First Vasectomy Procedure Successfully Performed on a Southern African Male Giraffe (Giraffa camelopardalis giraffa)

Zoo Biology, EarlyView.
First successful vasectomy in a southern African male giraffe, Giraffa camelopardis giraffa ABSTRACT This study reports the first successful vasectomy on a southern African male giraffe (Giraffa camelopardalis giraffa). The goal of the procedure was to create a teaser male for reproductive studies.
Francois Deacon, Willem Daffue, Edward Collin Albertyn, Susanna Maria Krüger, Ayanda Maqhashu, Jacquiline Goedhals, Andri Grobbelaar, Marike Badenhorst   +7 more
wiley   +1 more source

m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling

International Journal of Oral Science
N 1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown.
Shujin Li, Tian Feng, Yuantong Liu, Qichao Yang, An Song, Shuo Wang, Jun Xie, Junjie Zhang, Bifeng Yuan, Zhijun Sun   +9 more
doaj   +1 more source

ALKBH1‐mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression

Molecular Oncology, 2023
Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen, Hao Wang, Shuyi Mi, Liming Shao, Zhipeng Xu, Meng Xue   +5 more
doaj   +1 more source

Prognostic Significance of the Modified Glasgow Prognostic Score in Patients With Stage IV Melanoma Receiving Immune Checkpoint Inhibitors: A Single‐Center Retrospective Study

The Journal of Dermatology, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for malignant melanoma (MM). However, given variable response rates and potential toxicities, identifying robust biomarkers is crucial. We investigated whether the modified Glasgow Prognostic Score (mGPS) predicts treatment efficacy and toxicity in Asian patients with
Ken Horisaki, Shusuke Yoshikawa, Wataru Omata, Arata Tsutsumida, Yoshio Kiyohara   +4 more
wiley   +1 more source

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

Loud and Clear Epitranscriptomic m1A Signals: Now in Single-Base Resolution [PDF]

Molecular Cell, 2017
In this issue of Molecular Cell, Li et al. (2017) map N1-methyladenosine (m1A) with base precision, parsing the methylome into subsets differing in location, sequence-structure features, and catalyzing enzymes, thereby aiding functional investigation.
Dominissini, Dan, Rechavi, Gideon
openaire   +2 more sources

Impact of positive surgical margins on biochemical recurrence and metastases after radical prostatectomy

BJU International, EarlyView.
Objectives To evaluate the impact of the presence, extent and location of positive surgical margins (PSMs) on the risk of biochemical recurrence (BCR) and metastases in a nationwide cohort of patients who underwent radical prostatectomy (RP) and had 5 years of follow‐up.
Joost van Drumpt, Diederik Baas, Katja Aben, Arno van Leenders, Lambertus Kiemeney, Michiel Sedelaar, Peter Mulders, Jean‐Paul van Basten, Inge van Oort, Berdine Heesterman, Diederik Somford   +10 more
wiley   +1 more source

The PRAGMATIC pathway ‐ PRostate cancer diAGnosis and MAnagement Triage In Clinical care

BJU International, EarlyView.
Objectives To investigate whether nurse navigator‐led triaging of high‐risk patients may reduce prostate cancer (PCa) diagnosis and treatment times using an in‐house bespoke PRostate cancer diAGnosis and MAnagement Triage In the Clinial care pathway (PRAGMATIC) triaging system, as locally advanced/metastatic disease should be diagnosed and treated ...
Abhishek Sharma, Teresa Campbell, Sagar Kanabar, Hannah Soanes, Ganesh Sathanapally, Anthony Bates, Rincy John, Charlotte Adams, Aisling Brassill, Bryony Lennon, Sanjay Sinha, Louise Flaxman, Vanessa von Hasseln, Philip Camilleri, Ami Sabharwal, Philip Charlton, Gerard Andrade, Mark Tuthill, Andrew Protheroe, Alastair D. Lamb, Tom Leslie, Aaron Leiblich, Francisco Lopez, Clare Verrill, Fergus Gleeson, Ruth MacPherson, Freddie C. Hamdy, Richard Bell, Richard J. Bryant   +28 more
wiley   +1 more source