Results 91 to 100 of about 6,762 (168)

5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance

Journal of Translational Medicine
Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li, Tingting Liu, Yajing Dong, Qianqian Gao, Rongzhu Lu, Zhiyong Deng   +5 more
doaj   +1 more source

Heat Shock Transcription Factor OsHsfc1a Enhances Rice Seedling Thermotolerance by Regulating OsMFT1 and Preserving Chloroplast Structure Under Heat Stress

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1898-1915, March 2026.
ABSTRACT High‐temperature stress severely threatens rice (Oryza sativa L.) growth and productivity, particularly during the seedling stage, making heat tolerance an essential breeding target. In this study, we identified the heat shock transcription factor OsHsfc1a as a positive regulator of thermotolerance in rice seedlings.
Jingqin Lu, Junyu Chen, Hong Chen, Ziqiang Fan, Lin Lin, Chuanhe Liu, Xiaoxian Wu, Jilei Huang, Zhenlan Liu, Jing Li, Chuxiong Zhuang, Shaoyan Zheng   +11 more
wiley   +1 more source

m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets

Journal of Translational Medicine
5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye   +5 more
doaj   +1 more source

m5C related-regulator-mediated methylation modification patterns and prognostic significance in breast cancer

Scientific Reports
5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC ...
Zhe Wang, Jinpeng Li, Fucheng Wang, Chen Cheng, Xinpei Wu, Wendi Guo, Chenquan Li, Yinyi Luo, Guangwen Zhang, Sanyuan Zhang, Jie Hou, Wei Wang, Shiming Wang   +12 more
doaj   +1 more source

m6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD

Molecular Neurobiology
AbstractMajor depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by severe impairments in cognitive and functional capacities. This research was conducted to identify RNA modification-related gene signatures and associated functional pathways in MDD. Differentially expressed RNA modification-related genes in MDD were first
Xin Ren, Zhuxiao Feng, Xiaodong Ma, Lijuan Huo, Huiying Zhou, Ayu Bai, Shujie Feng, Ying Zhou, Xuchu Weng, Changhe Fan   +9 more
openaire   +2 more sources

mRNA m5C Alteration in Azacitidine Demethylation Treatment of Acute Myeloid Leukemia

Molecular Carcinogenesis
ABSTRACTThe DNA demethylating therapy with azacitidine (AZA) is a promising therapeutic strategy for elderly patients with acute myeloid leukemia (AML). AZA primarily inhibits DNA methylation, promotes cell differentiation and apoptosis in AML. However, as a cytosine nucleoside analog, AZA also has the potential to be incorporated into RNA molecules ...
Ziwei Chen, Yingyu Guo, Zaifeng Zhang, Chang Li, Lili Zhang, Ye Liu, Gaoyuan Sun, Fei Xiao, Ru Feng, Chunli Zhang   +9 more
openaire   +2 more sources

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques

Engineering Reports
5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir   +6 more
doaj   +1 more source

RNA m5C modification: from physiology to pathology and its biological significance

Frontiers in Immunology
RNA 5-methylcytosine (m5C) modification is a crucial epitranscriptomic mark that regulates RNA stability, processing, and translation. Emerging evidence highlights its essential role in various physiological processes, including cellular differentiation, stem cell maintenance, and immune responses.
Xi Chen, Xi Chen, Yixiao Yuan, Fan Zhou, Xiaobing Huang, Xiaobing Huang, Lihua Li, Jun Pu, Jun Pu, Yong Zeng, Xiulin Jiang   +10 more
openaire   +3 more sources

The multifaceted role of m5C RNA methylation in digestive system tumorigenesis

Frontiers in Cell and Developmental Biology
5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2. The m5C modification not only impacts RNA structure and stability but also governs post-transcriptional regulation by influencing RNA transport ...
Xinjun Hu, Yafeng Liu, Shujun Zhang, Kaijie Liu, Xinyu Gu   +4 more
openaire   +3 more sources

The role of m5C RNA modification in cancer development and therapy

Heliyon
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been ...
Yu, Li, Xu, Hongen, Xiong, Hanchu, Yang, Chunju, Wu, Ying, Zhang, Qiong   +5 more
openaire   +2 more sources