Results 71 to 80 of about 7,626 (175)

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Miranda E. Pitt, Jianshu Zhang, An N. T. Nguyen, Michael B. Hall, Leila Jebeli, Leo A. Featherstone, Garry S. A. Myers, Nichollas E. Scott, Lachlan J. M. Coin   +8 more
wiley   +1 more source

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
doaj   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

The role of m5C RNA modification in cancer development and therapy

Heliyon
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been ...
Yu, Li, Xu, Hongen, Xiong, Hanchu, Yang, Chunju, Wu, Ying, Zhang, Qiong   +5 more
openaire   +2 more sources

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle

Aging Cell, Volume 25, Issue 10, October 2026.
A combined analysis of short‐read and long‐read RNA‐seq demonstrates reduced isoform switching after an acute hypertrophic stimulus in aged muscle and identifies age‐dependent isoforms that may not be detected with total gene‐level analyses. ABSTRACT Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with ...
Pieter J. Koopmans, Abbey L. Stokes, Christopher E. Nelson, Yuan Wen, Ahmed Ismaeel, Kevin A. Murach   +5 more
wiley   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia

Immunity, Inflammation and Disease
Background Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is ...
Qiang Wen, ShouJun Wang, Lili Hong, Siyu Shen, Yibo He, Xianfu Sheng, Xiaofen Zhuang, Shiliang Chen, Ying Wang, Haifeng Zhuang   +9 more
doaj   +1 more source

The RNA m5C methylase NSUN4 protects retinal ganglion cells by regulating m5C methylation in the Hedgehog signaling pathway

Abstract Glaucoma, one of the leading causes of blindness worldwide, is characterized by retinal ganglion cell (RGC) damage. NOP2/Sun RNA methyltransferase 4 (NSUN4), a known 5-methylcytosine (m5C) writer, is an essential dual-function mitochondrial protein that facilitates both the process of methylation and the coordination of mitoribosome ...
Yahong Li, Dian Li, Chao Geng, Ruihua Wei, Yajian Duan   +4 more
openaire   +1 more source

Identification of m5C-related genes and subclusters in recurrent pregnancy loss

Journal of Assisted Reproduction and Genetics
Recurrent pregnancy loss (RPL), which occurs in 1-5% of couples and nearly half of the cases remain unexplained, is a complex condition influenced by multiple factors. Previous investigations have demonstrated the role of m5C-related genes (MRGs) in cancer prognosis and the significance of epigenetic modifications during pregnancy.
Huanmin Luo, Shuqing Li, Yuming Cao, Jinfeng Xu, Li Wang   +4 more
openaire   +2 more sources