Results 71 to 80 of about 7,166 (173)

Multilayer Proteome and Metabolome‐Based Validation Uncovers Combined Regulatory Roles and Predictive Values of 6 RNA Modifications and Cellular Senescence in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This study integrated multi‐omics data to analyze the synergistic effects of cellular senescence and RNA modifications on AD pathology. Transcriptome and proteome data were used to validate the stability of machine learning‐screened proteins and the model, while metabolomics data further revealed metabolic alterations during the progression of AD ...
Mengjie Tian, Ke Ye, Xinyi Chen, Lulu Liu, Xinyu Han, Tianhu Zheng, Xu Gao, Qing Xia, Fuyuan Li, Dayong Wang   +9 more
wiley   +1 more source

Protocol for single-base quantification of RNA m5C by pyrosequencing

STAR Protocols
5-methylcytosine (m5C) is a common RNA modification found in both coding and non-coding RNAs. Here, we present a protocol for RNA-m5C-pyroseq for quantitative, single-nucleotide resolution analysis of RNA methylation. We describe steps for designing primers for the target region of RNA, performing bisulfite conversion of RNA, and using pyrosequencing ...
Cayir, Akin, Böttcher, Yvonne
openaire   +2 more sources

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, Volume 255, Issue 7, Page 628-645, July 2026.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Projecting future damage costs of non‐native species using combined dynamical and cost–density equations

Ecological Applications, Volume 36, Issue 5, July 2026.
Abstract Biological invasions threaten biodiversity, economic stability, and public health, exacerbated by intensive global trade and transport. The economic costs of these invasions have exceeded US$2 trillion globally and continue to increase. Although past invasion costs have been described across various contexts, there are few robust projections ...
Danish A. Ahmed, Corey J. A. Bradshaw, Noor Tahat, Emma J. Hudgins, Pierre Courtois, Philip E. Hulme, Yuya Watari, Ali Serhan Tarkan, Ismael Soto, Phillip J. Haubrock, Paride Balzani, Ross N. Cuthbert   +11 more
wiley   +1 more source

Impacts of glacier retreat, greening, and a changing sediment supply on debris flows in contrasting monsoon‐dominated Himalayan climates

Earth Surface Processes and Landforms, Volume 51, Issue 7, July 2026.
We modified the SedCas model to assess how glacier retreat, vegetation growth, and sediment availability and erosion timing affect debris flow activity in Langtang and Mustang, Nepal. Results reveal that landscape change reduces sediment supply and runoff response, making debris flows smaller and less seasonally concentrated under future conditions ...
Varvara O. Bazilova, Jacob Hirschberg, Leon Duurkoop, Tjalling de Haas, Walter Immerzeel   +4 more
wiley   +1 more source

The RNA m5C methylase NSUN4 protects retinal ganglion cells by regulating m5C methylation in the Hedgehog signaling pathway

Abstract Glaucoma, one of the leading causes of blindness worldwide, is characterized by retinal ganglion cell (RGC) damage. NOP2/Sun RNA methyltransferase 4 (NSUN4), a known 5-methylcytosine (m5C) writer, is an essential dual-function mitochondrial protein that facilitates both the process of methylation and the coordination of mitoribosome ...
Yahong Li, Dian Li, Chao Geng, Ruihua Wei, Yajian Duan   +4 more
openaire   +1 more source

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +1 more source

Substrate selectivity of the human RNA m⁵C methyltransferase NSUN2. [PDF]

Nature
Canepa J, Ruiz-Arroyo VM, Schlamowitz NS, Nam Y.   +3 more
europepmc   +2 more sources

Identification of m5C-related genes and subclusters in recurrent pregnancy loss

Journal of Assisted Reproduction and Genetics
Recurrent pregnancy loss (RPL), which occurs in 1-5% of couples and nearly half of the cases remain unexplained, is a complex condition influenced by multiple factors. Previous investigations have demonstrated the role of m5C-related genes (MRGs) in cancer prognosis and the significance of epigenetic modifications during pregnancy.
Huanmin Luo, Shuqing Li, Yuming Cao, Jinfeng Xu, Li Wang   +4 more
openaire   +2 more sources