Results 71 to 80 of about 8,119 (209)
, 2022 BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Junqiang Li (491954) +14 more
core +1 more source
Translational Oncology5-Methylcytosine (m5C) is a ubiquitous RNA modification that is closely related to various cellular functions. However, no studies have comprehensively demonstrated the role of m5C in hepatocellular carcinoma (HCC) progression.
Qiyao Zhang +4 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
The Role of NSUN Family Genes in m5C Methylation and Diseases
Biomedicines5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes. Methylation writers are responsible for adding methyl groups to RNA molecules, regulating gene expression and cellular function through ...
Tao Jiang +3 more
openaire +3 more sources
Image2_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.PDF
, 2018 The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883) +5 more
core +1 more source
Wellcome Open Research, 2022 Background: Methylation of carbon-5 of cytosines (m5C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (
IC Navarro +6 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao +6 more
wiley +1 more source
Role of m5C methylation in digestive system tumors (Review)
Molecular Medicine ReportsCurrently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang, Li +6 more
openaire +2 more sources
BioMed Research International, 2022 Long noncoding RNAs (lncRNAs) are closely associated with a variety of tumors, including stomach adenocarcinoma (STAD). However, the role of 5‐methylcytosine‐ (m5C‐) related lncRNAs in STAD is still uncertain. This study investigated the value of m5C‐related lncRNAs in prognostic evaluation and immunotherapy of STAD.
Chenxi He +6 more
openaire +2 more sources
Table3_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX
, 2018 The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883) +5 more
core +1 more source