Results 61 to 70 of about 7,626 (175)

Transcriptome-Wide 5-Methylcytosine Functional Profiling of Long Non-Coding RNA in Hepatocellular Carcinoma

Cancer Management and Research, 2020
Yuting He,1,2,* Qingmiao Shi,1,2,* Yize Zhang,1,2,* Xin Yuan,1,2 Zujiang Yu1,2 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People’s Republic of China ...
He Y, Shi Q, Zhang Y, Yuan X, Yu Z
doaj  

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Identification and verification of an ALYREF-involved 5-methylcytosine based signature for stratification of prostate cancer patients and prediction of clinical outcome and response to therapies

Discover Oncology, 2023
Objectives Due to the heterogeneity of PCa, the clinical indicators used for PCa can't satisfy risk prognostication and personalized treatment.
Xiao Tan, Zhouda Cai, Guo Chen, Chao Cai, Jiahong Chen, Yingke Liang, Yangjia Zhuo, Jianming Liu, Liangliang Huang, Bin Ouyang, Yanni Wei, Zhenyu Jia, Junhong Deng, Weide Zhong, Jianming Lu   +14 more
doaj   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

RNA‐methyltransferase Nsun5 controls the maternal‐to‐zygotic transition by regulating maternal mRNA stability

Clinical and Translational Medicine, 2022
Background RNA modification‐induced ovarian dysgenesis appears to be necessary for ovary development. However, how m5C (5‐methylcytosine)‐coordinating modificatory transcripts are dynamically regulated during oogenesis, and ovarian development is unknown.
Chenyue Ding, Jiafeng Lu, Jincheng Li, Xiujuan Hu, Zhenxing Liu, Han Su, Hong Li, Boxian Huang   +7 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers

World Journal of Surgical Oncology, 2021
Background 5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m5C regulators and the outcomes of modified ...
Yuting He, Xiao Yu, Menggang Zhang, Wenzhi Guo   +3 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

RNA m5C methylation in cancer: mechanisms and biological impact

Oncogenesis
RNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C) influences key cellular processes such as proliferation, differentiation, apoptosis, and stress ...
Zhenyu Guan, Wendong Li, Yuting He, Wenzhi Guo   +3 more
openaire   +2 more sources

Protocol for single-base quantification of RNA m5C by pyrosequencing

STAR Protocols
5-methylcytosine (m5C) is a common RNA modification found in both coding and non-coding RNAs. Here, we present a protocol for RNA-m5C-pyroseq for quantitative, single-nucleotide resolution analysis of RNA methylation. We describe steps for designing primers for the target region of RNA, performing bisulfite conversion of RNA, and using pyrosequencing ...
Cayir, Akin, Böttcher, Yvonne
openaire   +2 more sources