Results 51 to 60 of about 8,119 (209)

SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer.

, 2023
A common mRNA modification is 5-methylcytosine (m5C), whose role in gene-transcript processing and cancer remains unclear. Here, we identify serine/arginine-rich splicing factor 2 (SRSF2) as a reader of m5C and impaired SRSF2 m5C binding as a potential ...
Putmans, Pascale, Deplus, Rachel, Li, Ang, Beckman, John I., Murisier, Frédéric, Beckman, John, Daniels, Danette, Bula Ibula Yanga, Yanga, Riching, Kristin M., Gupta, Yogesh, Lan, Jie, Mies, Frédérique, de Bony, Eric James, Abdel-Wahab, Omar, Yang, Ying, Ma, Hai-Li, Yang, Yun-Gui, Wang, Xing, Riching, Kristin, Hubert, Céline, Gupta, Yogesh K., Yoshimi, Akihide, Malbec, Lionel, Solary, Eric, Lin, Kuan-Ting, Zhang, Qing-Yang, Droin, Nathalie, Hassabi, Bouchra, Soares Da Costa, Christelle, Wang, Meng-Ke, Arya, Shailee, Bizet, Martin, Ma, Haili, Calonne, Emilie, Fuks, François   +34 more
core   +1 more source

Table6_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source

Presentation1_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.PDF

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source

Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers

Frontiers in Oncology
The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. It plays an important role in various biological processes, including cell metabolism, growth, apoptosis,
Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang   +5 more
doaj   +1 more source

Table2_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Table4_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source

DataSheet_1_Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy.zip

, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Junqiang Li (491954), Lei Hua (465535), Dongxue Gan (11652637), Haichuan Su (484434), Ting Zhao (434093), Shanshan Li (114847), Ronglin Wang (11652628), Yongdong Guo (10899774), Jie Min (117247), Liaoliao Zhu (11652634), Peixiang Ma (1535428), Jingjie Shi (11652631), Cheng Yang (273624), Chao Zhang (51048), Yang Song (88132)   +14 more
core   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Table1_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source