Results 51 to 60 of about 7,626 (175)
The Role of NSUN Family Genes in m5C Methylation and Diseases
Biomedicines5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes. Methylation writers are responsible for adding methyl groups to RNA molecules, regulating gene expression and cellular function through ...
Tao Jiang +3 more
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Nature CommunicationsRNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (m5C) is abundant across diverse RNAs and fitness-relevant across ...
Kristin A. Fluke +12 more
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Plant HormonesRNA methylation, particularly 5-methylcytosine (m5C) modification, has emerged as a pivotal regulatory layer governing plant development and stress responses.
Xinyao Cai +7 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao +6 more
wiley +1 more source
Role of m5C methylation in digestive system tumors (Review)
Molecular Medicine ReportsCurrently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang, Li +6 more
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Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson +3 more
wiley +2 more sources
BioMed Research International, 2022 Long noncoding RNAs (lncRNAs) are closely associated with a variety of tumors, including stomach adenocarcinoma (STAD). However, the role of 5‐methylcytosine‐ (m5C‐) related lncRNAs in STAD is still uncertain. This study investigated the value of m5C‐related lncRNAs in prognostic evaluation and immunotherapy of STAD.
Chenxi He +6 more
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Zhongliu Fangzhi YanjiuObjectiveTo construct a prognostic model of lung adenocarcinoma (LUAD) based on m5C modification-related genes and to explore its clinical value. MethodsBased on the LUAD data in TCGA, GSE30219, GSE31210, and GSE50081 cohorts, prognosis-related m5C ...
Fan YANG +5 more
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Construction of a serum diagnostic signature based on m5C-related miRNAs for cancer detection
Frontiers in Endocrinology, 2023 Currently, no clinically relevant non-invasive biomarkers are available for screening of multiple cancer types. In this study, we developed a serum diagnostic signature based on 5-methylcytosine (m5C)-related miRNAs (m5C-miRNAs) for multiple-cancer ...
Fuzhou Tang +7 more
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A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source