Results 51 to 60 of about 7,166 (173)
Nature CommunicationsRNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (m5C) is abundant across diverse RNAs and fitness-relevant across ...
Kristin A. Fluke +12 more
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Plant HormonesRNA methylation, particularly 5-methylcytosine (m5C) modification, has emerged as a pivotal regulatory layer governing plant development and stress responses.
Xinyao Cai +7 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao +6 more
wiley +1 more source
Role of m5C methylation in digestive system tumors (Review)
Molecular Medicine ReportsCurrently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang, Li +6 more
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YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA
Cancer Science, EarlyView.The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li +3 more
wiley +1 more source
Construction of a serum diagnostic signature based on m5C-related miRNAs for cancer detection
Frontiers in Endocrinology, 2023 Currently, no clinically relevant non-invasive biomarkers are available for screening of multiple cancer types. In this study, we developed a serum diagnostic signature based on 5-methylcytosine (m5C)-related miRNAs (m5C-miRNAs) for multiple-cancer ...
Fuzhou Tang +7 more
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Molecular insights and translational opportunities to enhance heat tolerance in rice
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
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Advanced Science, Volume 13, Issue 44, 7 August 2026.Defect‐configurational origins of the asymmetric apparent electrostrain are revealed in different piezoelectric ceramics via atomic‐scale visualization of defect configurations. Migration of oxygen vacancies leads to the electrobending effect in N2‐sintered BaTiO3, while defect dipoles in Ba0.99TiO2.99 generate true asymmetric electrostrain without ...
Jie Wang +7 more
wiley +1 more source
BioMed Research International, 2022 Long noncoding RNAs (lncRNAs) are closely associated with a variety of tumors, including stomach adenocarcinoma (STAD). However, the role of 5‐methylcytosine‐ (m5C‐) related lncRNAs in STAD is still uncertain. This study investigated the value of m5C‐related lncRNAs in prognostic evaluation and immunotherapy of STAD.
Chenxi He +6 more
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Zhongliu Fangzhi YanjiuObjectiveTo construct a prognostic model of lung adenocarcinoma (LUAD) based on m5C modification-related genes and to explore its clinical value. MethodsBased on the LUAD data in TCGA, GSE30219, GSE31210, and GSE50081 cohorts, prognosis-related m5C ...
Fan YANG +5 more
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