Results 81 to 90 of about 7,626 (175)
Scientific ReportsRNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang +6 more
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5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance
Journal of Translational MedicineRecent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li +5 more
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m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis
International Journal of GenomicsBackground Epigenetic medication, such as RNA 5‐methylcytosine (m5C), is well‐recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated. Methods
Shuxian Chen +5 more
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NSUN-Mediated m5C RNA Modification in Stem Cell Regulation
CellsRNA modifications comprise a core epigenetic dimension of gene regulation; among these, N6-methyladenosine (m6A) and 5-methylcytosine (m5C) have been most intensively investigated. While the functions of m6A in stem cell biology have been well characterized, the contributions of m5C remain comparatively less well defined.
Jiin Moon +3 more
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Scientific Reports5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC ...
Zhe Wang +12 more
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The role of m5C, m1A and m7G modifications in tumors of urinary system
Frontiers in Cell and Developmental BiologyMalignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Wei Xue +5 more
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Cell Death and DiseaseRNA 5-methylcytosine (m5C) plays a critical role in cancer, yet its functional mechanisms and therapeutic relevance in cervical cancer remain unclear.
Jiejie Liu +11 more
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The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
Frontiers in Cell and Developmental Biology5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2. The m5C modification not only impacts RNA structure and stability but also governs post-transcriptional regulation by influencing RNA transport ...
Xinjun Hu +4 more
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RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression
npj Precision Oncology5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li +3 more
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Function and Molecular Mechanism of m5C participating Malignant Tumors
Clinical Medicine and Pharmacology5-methylcytosine (m5C) plays a crucial role in gene expression regulation and RNA metabolism, and it is an important form of RNA epigenetic modification. This article systematically summarizes the molecular mechanisms of m5C regulation, including its dynamic regulatory network composed of methyltransferases, demethylases, and recognition proteins, and ...
Qingwen Zhong, Hongyu Deng
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