Results 81 to 90 of about 11,326 (215)
Frontiers in Cell and Developmental Biology, 2022 Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive digestive malignancy due to frequent late-stage diagnosis, rapid progression and resistance to therapy.
Duo Yun +7 more
doaj +1 more source
, 1994 We construct a $SU(3)^3$ supersymmetric gauge theory with a common gauge coupling g. Spontaneous breaking of this gauge group at a scale $M_X=1.3\times10^{16} $GeV gives naturally rise exactly to the Minimal Supersymmetric Standard Model $(MSSM)$ and ...
Amaldi +11 more
core +2 more sources
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
Molecular Cancer, 2023 Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang +19 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C
Yong Liu +7 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Ultrahigh energy neutrino scattering onto relic light neutrinos in galactic halo as a possible source of highest energy extragalactic cosmic rays [PDF]
, 1997 The diffuse relic neutrinos with light mass are transparent to Ultrahigh energy (UHE) neutrinos at thousands EeV, born by photoproduction of pions by UHE protons on relic 2.73 K BBR radiation and originated in AGNs at cosmic distances. However these UHE $
A. Salis +6 more
core +2 more sources
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Descriptors for terpene esters from chromatographic and partition measurements: Estimation of human odor detection thresholds [PDF]
, 2020 We have used gas chromatographic retention data together with other data to obtain Abraham descriptors for 30 terpene esters. These include the air-water partition coefficient, as log Kw, for which no experimental values are available for any terpene ...
Abraham, Michael H +2 more
core
Color Difference Makes a Difference: Four Planet Candidates around τ Ceti [PDF]
, 2017 The removal of noise typically correlated in time and wavelength is one of the main challenges for using the radial-velocity (RV) method to detect Earth analogues. We analyze τ Ceti RV data and find robust evidence for wavelength-dependent noise. We find
Anglada-Escudé, G. +6 more
core +4 more sources