Results 81 to 90 of about 8,119 (209)

Construction and Validation of A Prognostic Model of Lung Adenocarcinoma Based on m5C Modification-Related Genes

Zhongliu Fangzhi Yanjiu
ObjectiveTo construct a prognostic model of lung adenocarcinoma (LUAD) based on m5C modification-related genes and to explore its clinical value. MethodsBased on the LUAD data in TCGA, GSE30219, GSE31210, and GSE50081 cohorts, prognosis-related m5C ...
Fan YANG, Nongyan WANG, Meng FANG, Yingjiao ZHANG, Haiyan HU, Peng FANG   +5 more
doaj   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

The role of m5C RNA modification in cancer development and therapy

Heliyon
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been ...
Yu, Li, Xu, Hongen, Xiong, Hanchu, Yang, Chunju, Wu, Ying, Zhang, Qiong   +5 more
openaire   +2 more sources

Table5_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.XLSX

, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883), Jingjing Zhai (504585), Yujia Song (5113154), Enze Bian (5113157), Chuang Ma (175429), Jiantao Yu (1639270)   +5 more
core   +1 more source

Transcriptome-Wide 5-Methylcytosine Functional Profiling of Long Non-Coding RNA in Hepatocellular Carcinoma

Cancer Management and Research, 2020
Yuting He,1,2,* Qingmiao Shi,1,2,* Yize Zhang,1,2,* Xin Yuan,1,2 Zujiang Yu1,2 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People’s Republic of China ...
He Y, Shi Q, Zhang Y, Yuan X, Yu Z
doaj  

Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers

World Journal of Surgical Oncology, 2021
Background 5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m5C regulators and the outcomes of modified ...
Yuting He, Xiao Yu, Menggang Zhang, Wenzhi Guo   +3 more
doaj   +1 more source

Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C
Yong Liu, Shunzhen Zheng, Tao Wang, Ziqi Fang, Junjie Kong, Junjie Kong, Jun Liu, Jun Liu   +7 more
doaj   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Image_3_Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy.tif

, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Junqiang Li (491954), Lei Hua (465535), Dongxue Gan (11652637), Haichuan Su (484434), Ting Zhao (434093), Shanshan Li (114847), Ronglin Wang (11652628), Yongdong Guo (10899774), Jie Min (117247), Liaoliao Zhu (11652634), Peixiang Ma (1535428), Jingjie Shi (11652631), Cheng Yang (273624), Chao Zhang (51048), Yang Song (88132)   +14 more
core   +1 more source

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
doaj   +1 more source