Results 121 to 130 of about 11,326 (215)
5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance
Journal of Translational MedicineRecent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li +5 more
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Engineering a high-affinity methyl-CpG-binding protein [PDF]
, 2017 Core members of the MBD protein family (MeCP2, MBD1, MBD2 and MBD4) share a methyl-CpG-binding domain that has a specific affinity for methylated CpG sites in double-stranded DNA.
Adie, Karen +3 more
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NSUN-Mediated m5C RNA Modification in Stem Cell Regulation
CellsRNA modifications comprise a core epigenetic dimension of gene regulation; among these, N6-methyladenosine (m6A) and 5-methylcytosine (m5C) have been most intensively investigated. While the functions of m6A in stem cell biology have been well characterized, the contributions of m5C remain comparatively less well defined.
Jiin Moon +3 more
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Scientific Reports5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC ...
Zhe Wang +12 more
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5\u27-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5\u27-halves. [PDF]
, 2017 Transfer RNAs (tRNAs) are fundamental adapter components of translational machinery. tRNAs can further serve as a source of tRNA-derived noncoding RNAs that play important roles in various biological processes beyond translation.
Kirino, Yohei, Shigematsu, Megumi
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Symplectic fillings of Seifert fibered spaces [PDF]
, 2013 We give finiteness results and some classifications up to diffeomorphism of minimal strong symplectic fillings of Seifert fibered spaces over S^2 satisfying certain conditions, with a fixed natural contact structure.
Starkston, Laura
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The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
Frontiers in Cell and Developmental Biology5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2. The m5C modification not only impacts RNA structure and stability but also governs post-transcriptional regulation by influencing RNA transport ...
Xinjun Hu +4 more
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Engineering Reports5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi +6 more
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An unusual acute myeloid leukemia associated with hyper IgE: another case of AML‐M5c? [PDF]
, 2001 Haematologica. 2001 Feb;86(2):216-7. An unusual acute myeloid leukemia associated with hyper IgE: another case of AML-M5c? Lima M, Orfão A, Coutinho J, Ferreira G, Freitas I, Silvestre F, Justiça B.
COUTINHO, J. +6 more
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Function and Molecular Mechanism of m5C participating Malignant Tumors
Clinical Medicine and Pharmacology5-methylcytosine (m5C) plays a crucial role in gene expression regulation and RNA metabolism, and it is an important form of RNA epigenetic modification. This article systematically summarizes the molecular mechanisms of m5C regulation, including its dynamic regulatory network composed of methyltransferases, demethylases, and recognition proteins, and ...
Qingwen Zhong, Hongyu Deng
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