Results 121 to 130 of about 8,119 (209)

The multifaceted role of m5C RNA methylation in digestive system tumorigenesis

Frontiers in Cell and Developmental Biology
5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2. The m5C modification not only impacts RNA structure and stability but also governs post-transcriptional regulation by influencing RNA transport ...
Xinjun Hu, Yafeng Liu, Shujun Zhang, Kaijie Liu, Xinyu Gu   +4 more
openaire   +3 more sources

Correction to “[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner]”

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
wiley   +1 more source

Function and Molecular Mechanism of m5C participating Malignant Tumors

Clinical Medicine and Pharmacology
5-methylcytosine (m5C) plays a crucial role in gene expression regulation and RNA metabolism, and it is an important form of RNA epigenetic modification. This article systematically summarizes the molecular mechanisms of m5C regulation, including its dynamic regulatory network composed of methyltransferases, demethylases, and recognition proteins, and ...
Qingwen Zhong, Hongyu Deng
openaire   +1 more source

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression

npj Precision Oncology
5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li, Han Chen, Lang Bai, Hong Tang   +3 more
doaj   +1 more source

y9c/m5C-UBSseq: V0.1

<ul> <li>rewrite code using polars</li> <li>clean testing code.</li> </ul ...
Chang Y
core   +1 more source

Transcriptome-wide RNA 5-methylcytosine profiles of human iPSCs and iPSC-derived cardiomyocytes

Scientific Data
Cardiac regenerative therapy has recently progressed by reprogramming somatic cells into induced pluripotent stem cells (iPSCs) and advanced by large-scale differentiation-derived cardiomyocytes (hiPSC-CMs).
Szu-Ying Chen, Yi-Hsien Fang, Chen-Yu Huang, Jou-Hsien Wu, Yan-Shen Shan, Yen-Wen Liu, Po-Hsien Huang   +6 more
doaj   +1 more source

Recent research advances in RNA m5C methylation modification in liver diseases

RNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C).
Penghui Li, Shujun Zhang, Xinjun Hu, Wenjuan Chen, Lifan Zhang, Yafeng Liu, Xinyu Gu   +6 more
core   +1 more source

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
doaj   +1 more source

Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review). [PDF]

Mol Med Rep
Jiang Q, Gong Y, Zhai M, Tang T, Liu S.
europepmc   +1 more source

5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications. [PDF]

Cells
Yang Q, Salih SM, Wu R, Arora I, Mousa M, Al-Hendy A, Boyer TG.   +6 more
europepmc   +1 more source