Results 11 to 20 of about 6,762 (168)
Detection, molecular function and mechanisms of m5C in cancer
Clinical and Translational MedicineInterest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang +6 more
doaj +3 more sources
Protocol for profiling RNA m5C methylation at base resolution using m5C-TAC-seq
STAR ProtocolsSummary: RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection ...
Xiaoting Zhang +3 more
doaj +3 more sources
The 5-Methylcytosine RNA Modification in Hepatitis B Virus-Negative Hepatocellular Carcinoma: Insights From Long-Read Nanopore Sequencing. [PDF]
Mol CarcinogABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Sun T +12 more
europepmc +2 more sources
A CNN based m5c RNA methylation predictor
Scientific Reports, 2023 AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam +6 more
openaire +3 more sources
Cell Host & Microbe, 2019 In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C "writer" NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5' gag gene, and alters splicing at the A2 site.
Shelby, Winans, Karen, Beemon
openaire +2 more sources
The role of m5C methyltransferases in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that ...
Yan-Yue Wang +6 more
openaire +3 more sources
Staem5: A novel computational approach for accurate prediction of m5C site [PDF]
Molecular Therapy - Nucleic Acids, 2021 5-Methylcytosine (m5C) is an important post-transcriptional modification that has been extensively found in multiple types of RNAs. Many studies have shown that m5C plays vital roles in many biological functions, such as RNA structure stability and metabolism.
Di Chai +4 more
openaire +4 more sources
Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma [PDF]
Scientific Reports, 2021 Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development.
Xiao Yu +6 more
openaire +3 more sources
Mitomycin C binding to poly[d(G-m5C)] [PDF]
Biochemical Journal, 1995 Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA. C.d. and 31P-n.m.r. were used to characterize the poly[d(G-m5C)]-mitomycin cross-linked complexes, as well as the effects on the equilibrium between the B and Z forms of the
Portugal, José +1 more
openaire +3 more sources
m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome [PDF]
Nucleic Acids Research, 2021 Abstract 5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive collection and annotation of RNA 5-methylcytosine.
Jiongming Ma +9 more
openaire +2 more sources