Results 21 to 30 of about 6,762 (168)

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming

Journal of Cellular and Molecular Medicine, 2023
AbstractRecently, epigenetics showed essential roles in tumour microenvironment (TME) and immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) modification in TME remains unknown. According to 13 m5C regulators, we evaluated 412 BLCA patients from The Cancer Genome Atlas (TCGA) database.
Dali Yan, Yongsong Xie, Liyuan Huang, Yi Zhang, Runhuan Gu, Huaibing Xie, Xing Huang, Hao Luo   +7 more
openaire   +2 more sources

m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicine

Frontiers in Immunology, 2022
BackgroundThe RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-transcriptional modifications, with increasing evidence demonstrating its extensive involvement in the tumorigenesis and progression of various cancers.
Baoxiang Chen, Baoxiang Chen, Baoxiang Chen, Yiqing Xi, Jianhong Zhao, Jianhong Zhao, Yuntian Hong, Yuntian Hong, Yuntian Hong, Shunhua Tian, Shunhua Tian, Shunhua Tian, Xiang Zhai, Xiang Zhai, Xiang Zhai, Quanjiao Chen, Xianghai Ren, Xianghai Ren, Xianghai Ren, Lifang Fan, Xiaoyu Xie, Xiaoyu Xie, Xiaoyu Xie, Congqing Jiang, Congqing Jiang, Congqing Jiang   +25 more
doaj   +1 more source

Characterization of BisI Homologs

Frontiers in Microbiology, 2021
BisI is a sequence-specific and 5-methylcytosine (m5C)-dependent restriction endonuclease (REase), that cleaves the modified DNA sequence Gm5CNGC (G indicates that the cytosine opposite to G is modified).
Shuang-yong Xu, Elena V. Zemlyanskaya, Danila A. Gonchar, Zhiyi Sun, Peter Weigele, Alexey Fomenkov, Sergey Kh Degtyarev, Richard J. Roberts   +7 more
doaj   +1 more source

m5CPred-SVM:  A Novel Method for Predicting m5C Sites of RNA [PDF]

BMC Bioinformatics, 2020
Abstract Background: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functionssuch as RNA metabolism and cell fate decision. Through accurate identification of 5-methylcytosine (m5C) sites on RNA,researcherscanbetter understandthe exact role of 5 ...
Xiao Chen, Yi Xiong, Yinbo Liu, Yuqing Chen, Shoudong Bi, Xiaolei Zhu   +5 more
openaire   +3 more sources

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

Frontiers in Genetics, 2023
Background: Colorectal cancer (CRC) is a harmful cancer with high morbidity and poor prognosis. There is growing evidence that RNA methylation is closely related to the occurrence of cancer and its malignant biological behavior.
Yu Lin, Yu Lin, Yu Lin, Zhifang Zhao, Wenqiang Nie, Manting Huang, Jiazhong Cai, Yadong Wang, Hesong Wang, Yongmei Huang, Yang Bai, Yang Bai   +11 more
doaj   +1 more source

DNMT2-m5C-ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation-Mediated Notch Pathway. [PDF]

Adv Sci (Weinh)
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Yang S, Li J, Mao S, Zhao X, Liu D, Chen J, Fu J, Bu Y, Wu X, Liu S, Yu Q, Dong Q, Tang Z, Fang Y, Shi Y.   +14 more
europepmc   +2 more sources

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

RNA Biology, 2021
5-Methylcytosine (m5C) is a type of RNA modification that exists in tRNAs and rRNAs and was recently found in mRNA. Although mRNA m5C modification has been reported to regulate diverse biological process, its function in adipogenesis remains unknown.
Youhua, Liu, Yuanling, Zhao, Ruifan, Wu, Yushi, Chen, Wei, Chen, Yuxi, Liu, Yaojun, Luo, Chaoqun, Huang, Botao, Zeng, Xing, Liao, Guanqun, Guo, Yizhen, Wang, Xinxia, Wang   +12 more
openaire   +2 more sources

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

Journal of Translational Medicine, 2020
Background Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers.
Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He, Wenzhi Guo   +4 more
doaj   +1 more source