Interplay of RNA m<sup>6</sup>A/m<sup>1</sup>A/m<sup>5</sup>C/m<sup>7</sup>G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer. [PDF]
FASEB BioadvChen S, Mao J, Xu L, Lu L, Hao Y.
europepmc +1 more source
Global research trends on the relationship between RNA m<sup>5</sup>C modification and cancer progression: a comprehensive visualization and bibliometric analysis (1900-2024). [PDF]
Biophys RepYao P +6 more
europepmc +1 more source
NSUN4-mediated m5C RNA methylation protects retinal cells against excitotoxic injury via the SHH signaling pathway. [PDF]
PLoS OneLi Y, Li D, Geng C, Wei R, Duan Y.
europepmc +1 more source
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation [PDF]
Journal of Cellular Biochemistry, 2017 N6-methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown. Here, we show that in p21 3'UTR, NSUN2 catalyzes m5C modification and METTL3/METTL14 catalyzes m6A modification. Interestingly, methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by
Bin Jiang, Yali Dou, Myriam Gorospe
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DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation [PDF]
Molecular CellDNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) disorder.
Guoping Fan
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Annals of Medicine, 2023 To investigate the prognostic value of N6-methyladenosine (m6A)-, 5-methylcytosine (m5C)-, and N1-methyladenosine (m1A)-related genes in cervical cancer (CESC) and predicting immunotherapy response. We downloaded cervical cancer mRNA expression profiles,
Yiwen Mao, Caizhi Wang
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m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants
Current Biology, 2019 In plants, transcripts move to distant body parts to potentially act as systemic signals regulating development and growth. Thousands of messenger RNAs (mRNAs) are transported across graft junctions via the phloem to distinct plant parts. Little is known
Lei Yang +2 more
exaly +2 more sources
Recent insights into RNA m5C methylation modification in hepatocellular carcinoma
Biochimica Et Biophysica Acta: Reviews on CancerRNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Mingyu He
exaly +3 more sources
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NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression
Neoplasma, 2023Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts.
Guo-Fang, Sun, Hao, Ding
openaire +2 more sources
Target-Specific Profiling of RNA m5C Methylation Level Using Amplicon Sequencing
2021Mapping the position and quantifying the level of 5-methylcytosine (m5C) as a modification in different types of cellular RNA is an important objective in the field of epitranscriptomics. Bisulfite conversion has long been the gold standard for the detection of m5C in DNA, but it can also be applied to RNA.
Tennille, Sibbritt +5 more
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