Results 161 to 170 of about 171,203 (189)

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation [PDF]

Journal of Cellular Biochemistry, 2017
N6-methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown. Here, we show that in p21 3'UTR, NSUN2 catalyzes m5C modification and METTL3/METTL14 catalyzes m6A modification. Interestingly, methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by
Bin Jiang, Myriam Gorospe, Wengong Wang
exaly   +6 more sources

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation [PDF]

Molecular Cell
DNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) disorder.
Guoping Fan
exaly   +6 more sources

Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica Et Biophysica Acta: Reviews on Cancer
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Mingyu He
exaly   +3 more sources

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NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression

Neoplasma, 2023
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Our previous study has confirmed that XPD acts as an anti-oncogene and is downregulated in HCC. The mechanism of XPD downregulation in HCC is unclear. In this work, we obtained the datasets related to HCC patients from GSE76427, LIRI-JP, and TCGA-LIHC cohorts.
Guo-Fang, Sun, Hao, Ding
openaire   +2 more sources

Target-Specific Profiling of RNA m5C Methylation Level Using Amplicon Sequencing

2021
Mapping the position and quantifying the level of 5-methylcytosine (m5C) as a modification in different types of cellular RNA is an important objective in the field of epitranscriptomics. Bisulfite conversion has long been the gold standard for the detection of m5C in DNA, but it can also be applied to RNA.
Tennille, Sibbritt, Ulrike, Schumann, Andrew, Shafik, Marco, Guarnacci, Susan J, Clark, Thomas, Preiss   +5 more
openaire   +2 more sources

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

Dynamic landscape and regulation of m5C methylation in human tissues

Science China Life Sciences
5-methylcytosine (m5C) is a prevalent RNA modification that has various impacts on mRNA fate. Here, we generated 30 single-base resolution RNA m5C methylomes and revealed the dynamic nature of m5C of heart, muscle, lung, esophagus, stomach, pancreas, colon, jejunum, and rectum from 7 adult human individuals using RNA-BisSeq.
Ke, An, Ruijuan, Liu, Han, Yang, Luyao, Feng, Xinhan, Zhang, Xuran, Zhang, Mingyang, Hou, Jingyao, Wei, Xiao, Han, Boyang, Shi, Huan, Yao, Xing, Chen, Han, Wang, Xin, Tian   +13 more
openaire   +2 more sources

RNA methylation and breast cancer: insights into m6A, m7G and m5C

Molecular Biology Reports
Breast cancer remains the most commonly diagnosed cancer in female worldwide, marked by its molecular diversity and complex subtypes. Despite progress in targeted therapies, tumor heterogeneity and treatment resistance continue to present major challenges. Recent studies emphasize the crucial role of RNA modifications in cancer biology, with nearly 200
Yuhan, Dai, Shuhan, Zhao, Huilin, Chen, Wenxin, Yu, Ziyi, Fu, Yangyang, Cui, Hui, Xie   +6 more
openaire   +2 more sources

The role of m5C RNA methylation regulators in the diagnosis and immune microenvironment of osteoarthritis

Computer Methods in Biomechanics and Biomedical Engineering
The 5-methylcytosine (m5C) is a common post-transcriptional RNA methylation modification and is involved in the pathological process of many diseases. However, little is known about the role of m5C in osteoarthritis (OA). OA gene data and the corresponding information were downloaded from the Gene Expression Omnibus database. Based on 36 m5C regulators,
Kehan, Li, Shengjie, Wang, Chenyue, Xu, Zhengyi, Ni, Xiurong, Wang, Fei, Wang   +5 more
openaire   +2 more sources