Results 161 to 170 of about 5,629 (182)

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity

Phytomedicine
Doxorubicin (DOX)-induced myocardial cardiotoxicity (DIC) severely limits its clinical application, and there is no optimal therapeutic agent available. Recent studies revealed that activation of BNIP3-mediated mitophagy and the inhibition of m5C RNA methylation played a crucial role in DIC. Isoliquiritin (ISL) has remarkable cardiac protective effect.
Jiaqi Fu, Xing Cui
exaly   +3 more sources

Dynamic landscape and regulation of m5C methylation in human tissues

Science China Life Sciences
5-methylcytosine (m5C) is a prevalent RNA modification that has various impacts on mRNA fate. Here, we generated 30 single-base resolution RNA m5C methylomes and revealed the dynamic nature of m5C of heart, muscle, lung, esophagus, stomach, pancreas, colon, jejunum, and rectum from 7 adult human individuals using RNA-BisSeq.
Ke, An, Ruijuan, Liu, Han, Yang, Luyao, Feng, Xinhan, Zhang, Xuran, Zhang, Mingyang, Hou, Jingyao, Wei, Xiao, Han, Boyang, Shi, Huan, Yao, Xing, Chen, Han, Wang, Xin, Tian   +13 more
openaire   +2 more sources

RNA methylation and breast cancer: insights into m6A, m7G and m5C

Molecular Biology Reports
Breast cancer remains the most commonly diagnosed cancer in female worldwide, marked by its molecular diversity and complex subtypes. Despite progress in targeted therapies, tumor heterogeneity and treatment resistance continue to present major challenges. Recent studies emphasize the crucial role of RNA modifications in cancer biology, with nearly 200
Yuhan, Dai, Shuhan, Zhao, Huilin, Chen, Wenxin, Yu, Ziyi, Fu, Yangyang, Cui, Hui, Xie   +6 more
openaire   +2 more sources

The role of m5C RNA methylation regulators in the diagnosis and immune microenvironment of osteoarthritis

Computer Methods in Biomechanics and Biomedical Engineering
The 5-methylcytosine (m5C) is a common post-transcriptional RNA methylation modification and is involved in the pathological process of many diseases. However, little is known about the role of m5C in osteoarthritis (OA). OA gene data and the corresponding information were downloaded from the Gene Expression Omnibus database. Based on 36 m5C regulators,
Kehan, Li, Shengjie, Wang, Chenyue, Xu, Zhengyi, Ni, Xiurong, Wang, Fei, Wang   +5 more
openaire   +2 more sources

Exploration of the Prognostic Value of m5C Methylation Protein NOP2 and NSUN6 in Colon Cancer

Genetic Testing and Molecular Biomarkers
Background: Colorectal cancer is a prevalent malignancy with high incidence and poor prognosis. This study explores the clinical significance of 5-methylcytosine RNA modification factors, specifically the NOP2/Sun RNA Methyltransferase (NSUN) family, in colorectal cancer.
Bin Jiang, Jie Li, Jianguo Wang
openaire   +2 more sources

Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification

Phytomedicine
Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a traditional Chinese medicine, has been widely utilized in the management of cardiovascular diseases; however, its potential mechanisms for reversing ...
Yahua, Wu, Xiaomin, Huang, Yun, He, Junjie, Chang, Xiaoxia, Fang, Pengju, Kang, Na, Feng, Rui, Liu, Pingping, Xiao, Dandan, Shi, Qiufang, Zhang, Yan, Ding, Wenjun, Zhang, Xiju, He   +13 more
openaire   +2 more sources

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis.

Journal of visualized experiments : JoVE, 2020
Secondary base modifications on RNA, such as m5C, affect the structure and function of the modified RNA molecules. Methylated RNA Immunoprecipitation and sequencing (MeRIP-seq) is a method that aims to enrich for methylated RNA and ultimately identify modified transcripts.
Saplaoura, Eleftheria, Perrera, Valentina, Colot, Vincent, Kragler, Friedrich   +3 more
openaire   +3 more sources

NSUN2 contributes to the RB malignant progression and Glycolysis by mediating the m5C methylation modification of HKDC1

Journal of Bioenergetics and Biomembranes
Retinoblastoma (RB) is a malignant neoplasm originating from photoreceptor precursor cells that is common in children under 3 years of age. NOP2/Sun RNA methyltransferase family member 2 (NSUN2) is a major methyltransferase that catalyzes mammalian mRNA 5-methylcytosine (m5C) modification and has been implicated in a variety of diseases, but its ...
Jing, Guan, Lili, Lu, Yuantong, Jiang
openaire   +2 more sources

NSUN2 enhances the stability of PTPRD mRNA via m5C methylation to aggravate astrocyte activation

Brain Research
This study attempts to investigate the functional role of NOP2/Sun RNA methyltransferase 2 (NSUN2) in astrocyte activation and inflammatory response following traumatic brain injury (TBI), and explore its mechanism in regulating A1 astrocyte phenotype activation through m5C methylation-mediated stabilization of protein tyrosine phosphatase receptor ...
Jianmin, Wang, Xiaoyu, Zhang, Tong, Zhang, Qunling, Yang, Jiaojiao, Liu   +4 more
openaire   +2 more sources