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PhytomedicineDoxorubicin (DOX)-induced myocardial cardiotoxicity (DIC) severely limits its clinical application, and there is no optimal therapeutic agent available. Recent studies revealed that activation of BNIP3-mediated mitophagy and the inhibition of m5C RNA methylation played a crucial role in DIC. Isoliquiritin (ISL) has remarkable cardiac protective effect.
Xing Cui, Fu Jiaqi, Manya Yu
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Exploration of the Prognostic Value of m5C Methylation Protein NOP2 and NSUN6 in Colon Cancer
Genetic Testing and Molecular BiomarkersBackground: Colorectal cancer is a prevalent malignancy with high incidence and poor prognosis. This study explores the clinical significance of 5-methylcytosine RNA modification factors, specifically the NOP2/Sun RNA Methyltransferase (NSUN) family, in colorectal cancer.
Bin Jiang, Jie Li, Jianguo Wang
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Phytomedicine
Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a traditional Chinese medicine, has been widely utilized in the management of cardiovascular diseases; however, its potential mechanisms for reversing ...
Yahua, Wu +13 more
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Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a traditional Chinese medicine, has been widely utilized in the management of cardiovascular diseases; however, its potential mechanisms for reversing ...
Yahua, Wu +13 more
openaire +2 more sources
Journal of Bioenergetics and Biomembranes
Retinoblastoma (RB) is a malignant neoplasm originating from photoreceptor precursor cells that is common in children under 3 years of age. NOP2/Sun RNA methyltransferase family member 2 (NSUN2) is a major methyltransferase that catalyzes mammalian mRNA 5-methylcytosine (m5C) modification and has been implicated in a variety of diseases, but its ...
Jing, Guan, Lili, Lu, Yuantong, Jiang
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Retinoblastoma (RB) is a malignant neoplasm originating from photoreceptor precursor cells that is common in children under 3 years of age. NOP2/Sun RNA methyltransferase family member 2 (NSUN2) is a major methyltransferase that catalyzes mammalian mRNA 5-methylcytosine (m5C) modification and has been implicated in a variety of diseases, but its ...
Jing, Guan, Lili, Lu, Yuantong, Jiang
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NSUN2 enhances the stability of PTPRD mRNA via m5C methylation to aggravate astrocyte activation
Brain ResearchThis study attempts to investigate the functional role of NOP2/Sun RNA methyltransferase 2 (NSUN2) in astrocyte activation and inflammatory response following traumatic brain injury (TBI), and explore its mechanism in regulating A1 astrocyte phenotype activation through m5C methylation-mediated stabilization of protein tyrosine phosphatase receptor ...
Jianmin, Wang +4 more
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Analytica Chimica Acta
Sensitive and efficient detection of RNA methylation sites is considered an integral part of epigenetic assessment. Contrary to previous studies on the detection of RNA m5C or m6A methylation alone, this study innovatively designed a biosensor capable of detecting RNA m5C or m6A methylation at the same time.
Mimi Li +12 more
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Sensitive and efficient detection of RNA methylation sites is considered an integral part of epigenetic assessment. Contrary to previous studies on the detection of RNA m5C or m6A methylation alone, this study innovatively designed a biosensor capable of detecting RNA m5C or m6A methylation at the same time.
Mimi Li +12 more
openaire +2 more sources
HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5C Methylation of Atf7 mRNA
Advanced Science, 2023Yuhui Zhang, Xin-Zhe Chen
exaly
Nucleotide-Level Profiling of m5C RNA Methylation
2016Tennille Sibbritt +3 more
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