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A strategy for electrochemical biosensing based on dendritic HCR amplification for detection of RNA m5C and m6A methylation

Analytica Chimica Acta
Sensitive and efficient detection of RNA methylation sites is considered an integral part of epigenetic assessment. Contrary to previous studies on the detection of RNA m5C or m6A methylation alone, this study innovatively designed a biosensor capable of detecting RNA m5C or m6A methylation at the same time.
Mimi Li   +12 more
openaire   +2 more sources

Unveiling the landscape of m5C RNA methylation in lung cancer: From molecular mechanisms to therapeutic opportunities

Biochemical and Biophysical Research Communications
RNA methylation has emerged as a critical frontier in epitranscriptomics, with 5-methylcytosine (m5C) drawing particular attention for its multilayered roles in post-transcriptional gene regulation. Recent studies demonstrate that m5C modulates diverse biological processes by stabilizing RNA transcripts, promoting nuclear export, shaping translational ...
Xiaoyou, Zhong   +4 more
openaire   +2 more sources

Nsun2-mediated m5C methylation of Ncor1 exacerbates sepsis-induced cardiomyopathy by promoting mitochondrial dysfunction

Free Radical Biology and Medicine
Sepsis-induced cardiomyopathy (SIC) is a severe complication of sepsis characterized by mitochondrial dysfunction and impaired myocardial contractility, yet its molecular pathogenesis remains incompletely understood. In this study, we demonstrate that excessive mitochondrial fission plays a pivotal role in SIC, contributing to inflammation, oxidative ...
Chan, Chen   +5 more
openaire   +2 more sources

HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5C Methylation of Atf7 mRNA

Advanced Science, 2023
Xue-Mei Zhao   +2 more
exaly  

Nucleotide-Level Profiling of m5C RNA Methylation

2016
Tennille Sibbritt   +3 more
openaire   +1 more source

Erratum: Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis.

Journal of visualized experiments : JoVE
An erratum was issued for: Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis. The author list was updated. The author list was updated from: Eleftheria Saplaoura1, Valentina Perrera2, Friedrich Kragler1 1Max Planck Institute of Molecular Plant Physiology 2Department of Molecular Medicine, Medical School, University of ...
openaire   +1 more source

m5C mRNAs on the move

Nature Reviews Molecular Cell Biology, 2019
Kim Baumann, Baumann Kim
exaly  

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