Results 181 to 190 of about 814,114 (202)

Changes of RNA m6A/m5C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas

Cell Biochemistry and Biophysics
N6-methyladenine (m6A) and 5-methylcytosine (m5C) are two common forms of RNA methylation that play an important role in the epigenetics of type 2 diabetes mellitus (T2DM). One type of cell death, ferroptosis, has been implicated in islet β-cell damage in T2DM.
Xiaoyu Liu, Nan Wang, Shiyan Gu, Zuoshun He   +3 more
openaire   +2 more sources

ALYREF regulates the m5C modification and stability of BIRC5 mRNA to promote ovarian cancer progression

Pathology - Research and Practice
Ovarian cancer (OC) is the most dangerous cancer among gynecological tumors, which poses a significant threat to women's health worldwide. 5-methylcytosine (m5C) plays a significant role in regulating tumor development. The RNA methyltransferase Aly/REF export factor (ALYREF) is one of the m5C-modified RNA-reading proteins.
Yongju, Tian, Jianmeng, Liu, Lei, Sun, Xiaoguang, Wang   +3 more
openaire   +2 more sources

NSUN2 contributes to the RB malignant progression and Glycolysis by mediating the m5C methylation modification of HKDC1

Journal of Bioenergetics and Biomembranes
Retinoblastoma (RB) is a malignant neoplasm originating from photoreceptor precursor cells that is common in children under 3 years of age. NOP2/Sun RNA methyltransferase family member 2 (NSUN2) is a major methyltransferase that catalyzes mammalian mRNA 5-methylcytosine (m5C) modification and has been implicated in a variety of diseases, but its ...
Jing, Guan, Lili, Lu, Yuantong, Jiang
openaire   +2 more sources

NSUN2 Promotes Prostate Cancer Cell Proliferation and Migration Through m5C Modifications of YES1

Molecular Carcinogenesis
ABSTRACT Prostate cancer (PCa) is one of the most common genitourinary malignancies in men worldwide. As a 5‐methylcytosine (m5C) methyltransferase, NSUN2 has been implicated in regulating PCa progression. This study aimed to investigate the role of NSUN2 in PCa and elucidate its underlying mechanisms.
Tianming Chen, Xiaokang Yang, Shuai Su, Delin Wang   +3 more
openaire   +2 more sources

NOP2-mediated mRNA m5C modification in anaplastic thyroid cancer

This study aims to explore the role of mRNA m5C modification mediated by NOP2 in the progression of anaplastic thyroid cancer and its underlying molecular mechanisms.
openaire   +1 more source

NSUN2 aggravates M1 macrophage polarization in arthritis progression through m5C modification of CCL2

Molecular Immunology
Arthritis is an inflammatory disease characterized by multifactorial pathogenesis in joints or surrounding tissues. M1 macrophage polarization is a key pathological feature of arthritis, and m⁵C RNA modification has been implicated in disease progression.
Chunlei, He, Junhua, Zhang, Geer, Deli, Kai, Zhao, Lulin, Liu, Baojian, Lai, Meiyu, Hu, Huabin, He   +7 more
openaire   +2 more sources

NOP2 Promotes Inflammation and Apoptosis in Chronic Obstructive Pulmonary Disease by Enhancing m5C Modification of NFKB1

Journal of Biochemical and Molecular Toxicology
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder. N5‐methylcytosine (m5C) RNA modification, catalyzed by methyltransferases such as NOP2, plays a crucial role in regulating RNA stability and gene expression.
Jingjing Hu, Caihong Guan, Xue Song, Lu Wang   +3 more
openaire   +2 more sources

Afzelin alleviates osteoarthritis by suppressing pyroptosis through decreasing NSUN5-mediated NLRC4 m5C modification

International Immunopharmacology
Osteoarthritis (OA) is characterized by the destruction of chondrocytes, in which chondrocyte pyroptosis has been demonstrated to be a key mechanism driving OA progression. 5-Methylcytosine (m5C) modification has been implicated in various biological processes, yet its role in mediating OA remains poorly understood.
Hainan, Hong, Shuai, He, Jianqiang, Huang, Zhenghua, Hong, Lizhi, Wu, Yuhang, Zhang, Huifeng, Xi   +6 more
openaire   +2 more sources

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

Proceedings of the National Academy of Sciences of the United States of America, 2022
Yufei Xiang, Li Lan
exaly  

Development and Validation of a Novel Gene Signature for Predicting the Prognosis by Identifying m5C Modification Subtypes of Cervical Cancer

Frontiers in Genetics, 2021
Di Wang, Jia Zeng, Jing Yu
exaly