Results 171 to 180 of about 814,114 (202)

Emerging Role of RNA m5C Modification in Cardiovascular Diseases

Journal of Cardiovascular Translational Research, 2022
Epitranscriptomics is the emerging field of research that comprises the study of epigenetics changes in RNAs. Progressing development in the field of epigenetics has helped to manage and comprehend human diseases. RNA methylation regulates all aspects of RNA functions, which are involved in the pathogenesis of human diseases.
Arumugam Paramasivam
exaly   +3 more sources

Recent insights into RNA m5C methylation modification in hepatocellular carcinoma

Biochimica Et Biophysica Acta: Reviews on Cancer
RNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Mingyu He
exaly   +3 more sources

The role of m5C RNA modification in cancer development and therapy

Heliyon
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been ...
Hanchu Xiong, Hongen Xu
exaly   +3 more sources

NSUN-Mediated m5C RNA Modification in Stem Cell Regulation

Cells
RNA modifications comprise a core epigenetic dimension of gene regulation; among these, N6-methyladenosine (m6A) and 5-methylcytosine (m5C) have been most intensively investigated. While the functions of m6A in stem cell biology have been well characterized, the contributions of m5C remain comparatively less well defined.
Seung-Kyoon Kim
exaly   +3 more sources

The emerging role of m5C modification in viral infection

Virology
5-Methylcytosine (m5C) modification is a dynamic and reversible post-transcriptional process that has garnered significant attention due to its regulatory role in viral infections and host innate immune responses. Advances in m5C detection technologies have spurred research into its influence on viral infection pathways.
Jincheng Li, Leiliang Zhang
openaire   +2 more sources

The Role of RNA m5C Modification in Central Nervous System Diseases

Discovery Medicine
As advances in RNA modification research progress, the significance of 5-methylcytosine (m5C) modification is being increasingly acknowledged. m5C undergoes modification by the methyltransferase NOP2/Sun domain (NSUN) family/DNA methyltransferase (DNMT) family (writer) and is removed by demethylases (eraser), including the ten-eleven translocation (TET)
Peiyan, Wu, Jiaxiang, Gao, Guangming, Lan, Yichao, Wang   +3 more
openaire   +2 more sources

m5C modification of LINC00324 promotes angiogenesis in glioma through CBX3/VEGFR2 pathway

International Journal of Biological Macromolecules
Angiogenesis plays a major role in tumor initiation, progression, and metastasis. This is why finding antiangiogenic targets is essential in the treatment of gliomas. In this study, NSUN2 and LINC00324 were significantly upregulated in conditionally cultured glioblastoma endothelial cells (GECs).
Aini, Pan, Yixue, Xue, Xuelei, Ruan, Weiwei, Dong, Di, Wang, Yunhui, Liu, Libo, Liu, Yang, Lin, Tiange, E, Hongda, Lin, Hailing, Xu, Xiaobai, Liu, Ping, Wang   +12 more
openaire   +2 more sources

m5C-Seq: Machine learning-enhanced profiling of RNA 5-methylcytosine modifications

Computers in Biology and Medicine
Epigenetic modifications, particularly RNA methylation and histone alterations, play a crucial role in heredity, development, and disease. Among these, RNA 5-methylcytosine (m5C) is the most prevalent RNA modification in mammalian cells, essential for processes such as ribosome synthesis, translational fidelity, mRNA nuclear export, turnover, and ...
Zeeshan Abbas, Mobeen Ur Rehman, Hilal Tayara, Seung Won Lee 0001, Kil To Chong 0001   +4 more
openaire   +3 more sources

Simultaneous profiling of ac4C and m5C modifications from nanopore direct RNA sequencing

International Journal of Biological Macromolecules
N4-acetylcytidine (ac4C) and 5-methylcytidine (m5C) play important roles in mRNA stability, translation efficiency, and cellular stress responses. Current methods for detecting RNA modifications from nanopore sequencing data do not support simultaneous de novo identification of both modifications.
You, Wu, Wenna, Shao, Shuai, Liu, Liyuan, Wang, Pengfei, Xu, Xingpeng, Zhang, Haihan, Song, Xiaofei, Li, Jian, Wang, Xiang, Yu   +9 more
openaire   +2 more sources

Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification

Phytomedicine
Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a traditional Chinese medicine, has been widely utilized in the management of cardiovascular diseases; however, its potential mechanisms for reversing ...
Yahua, Wu, Xiaomin, Huang, Yun, He, Junjie, Chang, Xiaoxia, Fang, Pengju, Kang, Na, Feng, Rui, Liu, Pingping, Xiao, Dandan, Shi, Qiufang, Zhang, Yan, Ding, Wenjun, Zhang, Xiju, He   +13 more
openaire   +2 more sources