Results 11 to 20 of about 26,139 (253)
m6a RNA methylation: the implications for health and disease [PDF]
Journal of Cancer Science and Clinical Oncology, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +4 more sources
Editorial: m6A methylation and cancer immunity. [PDF]
Front ImmunolChen Q, Yuan H, Wu PF.
europepmc +2 more sources
RNA m6A methylation regulators in ovarian cancer [PDF]
Cancer Cell International, 2021 AbstractN6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC)
Jialu Guo +3 more
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m6A RNA Methylation in Cardiovascular Diseases [PDF]
Molecular Therapy, 2020 Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention. There is an urgent need to discover more effective therapeutic strategies, which would be facilitated by a more in-depth understanding of CVDs and their underlying molecular mechanisms.
Siyi, Wu +3 more
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RNA m6A methylation across the transcriptome
Molecular Cell, 2023 Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
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Detecting m6A methylation regions from Methylated RNA Immunoprecipitation Sequencing
Bioinformatics, 2021 AbstractMotivationThe post-transcriptional epigenetic modification on mRNA is an emerging field to study the gene regulatory mechanism and their association with diseases. Recently developed high-throughput sequencing technology named Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) enables one to profile mRNA epigenetic modification ...
Zhenxing Guo +4 more
openaire +2 more sources
m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoporosis is a prevalent bone disease of the aging population, which is characterized by a decrease in bone mass because of the imbalance of bone metabolism. Although the prevention and treatment of osteoporosis have been explored by different researchers, the mechanisms underlying osteoporosis are not clear exactly.
Mei Huang +10 more
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Association between ankylosing spondylitis and m6A methylation
Journal of Orthopaedic Surgery and Research, 2023 Abstract Background N6-methyl adenosine (m6A) is the most common reversible mRNA modification in eukaryotes implicated in key roles in various biological processes. The purpose of our analysis was to examine the association of ankylosing spondylitis (AS) with m6A methylation. Method
Zhiwei Luan, Yansong Wang
openaire +3 more sources
Analysis approaches for the identification and prediction of N6-methyladenosine sites
Epigenetics, 2023 The global dynamics in a variety of biological processes can be revealed by mapping transcriptional m6A sites, in particular full-transcriptome m6A.
Yuwei Yang +7 more
doaj +1 more source
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source