Results 21 to 30 of about 26,139 (253)
Ecotoxicology and Environmental Safety, 2022 Silicosis is one of the most severe interstitial lung fibrosis diseases worldwide, caused by crystalline silica exposure. While the mechanisms and pathogenesis underlying silicosis remained unknown.
Yingdie Zhang +8 more
doaj +1 more source
Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]
, 2020 Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin +4 more
core +2 more sources
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
doaj +1 more source
RNA m6A methylation regulators in endometrial cancer (Review)
International Journal of Oncology, 2022 As one of the three major malignant tumor types of the female reproductive system, endometrial cancer (EC) is the most prevalent gynecologic cancer in developed countries. In recent years, the incidence of EC has increased worldwide, threatening the health and well‑being of women.
Shen, Siyi +4 more
openaire +2 more sources
The m6A epitranscriptome on neural development and degeneration
Journal of Biomedical Science, 2021 N 6-methyladenosine (m6A) is the most prevalent, conserved, and abundant RNA modification of the mRNAs of most eukaryotes, including mammals. Similar to epigenetic DNA modifications, m6A has been proposed to function as a critical regulator for gene ...
Ya-Ping Yen, Jun-An Chen
doaj +1 more source
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation
Cell Reports, 2018 Summary: Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N6-methyladenosine (m6A) mRNA methylation impacts circadian regulation of lipid metabolism
Xiang Zhong +17 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear.
Huan Li +11 more
doaj +1 more source
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
Characterization of m6A methylation modifications in gastric cancer
Aging, 2023 Widely recognized as an essential epitranscriptomic modification, RNA N6-methyladenosine (m6A) is involved in both physiological and pathological processes. Here, we want to investigate m6A modification's potential roles in gastric cancer. Gastric cancer samples were selected from TCGA-STAD and GEO (GSE84426, GSE84433) datasets.
Yin, Wei +5 more
openaire +2 more sources
Research Progress on Long Noncoding RNAs and N6-Methyladenosine in Hepatocellular Carcinoma
Frontiers in Oncology, 2022 N6-methyladenosine (m6A) is an epigenetic modification that widely exists in long noncoding RNAs (lncRNAs) and is involved in the regulation of oncogenes or tumor suppressor genes that form complex enzymes to affect the occurrence of tumors. The abnormal
Wenjie Zhang +10 more
doaj +1 more source