Results 31 to 40 of about 26,139 (253)
Transcriptome-wide m6A methylation in natural yellow leaf of Catalpa fargesii
Frontiers in Plant Science, 2023 N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA, and involved in various biological processes in plants. However, the distribution features and functions of mRNA m6A methylation have been poorly explored in
Yu Zhang +9 more
doaj +1 more source
The role of m6A RNA methylation in cancer metabolism [PDF]
Molecular Cancer, 2022 AbstractMetabolic reprogramming is one of the main characteristics of malignant tumors, which is due to the flexible changes of cell metabolism that can meet the needs of cell growth and maintain the homeostasis of tissue environments. Cancer cells can obtain metabolic adaptation through a variety of endogenous and exogenous signaling pathways, which ...
Yuanyuan An, Hua Duan
openaire +3 more sources
Genome Biology, 2019 Background Methylation of nucleotides, notably in the forms of 5-methylcytosine (5mC) in DNA and N6-methyladenosine (m6A) in mRNA, carries important information for gene regulation.
Leilei Zhou, Shiping Tian, Guozheng Qin
doaj +1 more source
Emerging role of m6A methylation modification in ovarian cancer [PDF]
Cancer Cell International, 2021 Abstractm6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism. Aberrant levels of m6A and its regulators, which can predict the survival and outcomes of cancer patients, are involved in tumorigenesis, metastasis and resistance. Ovarian cancer (OC)
Lin-Lin Chang +6 more
openaire +3 more sources
Cyclin D1 integrates G9a-mediated histone methylation. [PDF]
, 2019 Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency.
Casimiro, Mathew C. +13 more
core +2 more sources
The Biogenesis and Precise Control of RNA m6A Methylation [PDF]
Trends in Genetics, 2020 N6-Methyladenosine (m6A) is the most prevalent internal RNA modification in mRNA, and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A for gene expression regulation and cell fate decisions has been well acknowledged in the past few years.
Huilin, Huang +2 more
openaire +2 more sources
Frontiers in Immunology, 2021 N6-methyladenosine (m6A) methylation is one of the most common modifications of RNA in eukaryotic cells, and is mainly regulated by m6A methyltransferases (writers), m6A demethylases (erasers), and m6A binding proteins (readers).
Liting Guo +5 more
doaj +1 more source
Genomics, Proteomics & Bioinformatics, 2023 As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs (lncRNAs), N6-methyladenosine (m6A) RNA methylation has been shown to participate in essential biological processes.
Bowen Song +8 more
doaj +1 more source
m6A RNA methylation regulates the fate of endogenous retroviruses
Nature, 2021 Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle1. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases2,3.
Chelmicki, Tomasz +9 more
openaire +2 more sources
Role of m6A Methylation in the Occurrence and Development of Heart Failure
Frontiers in Cardiovascular Medicine, 2022 N6-methyladenosine (m6A) RNA methylation is one of the most common epigenetic modifications in RNA nucleotides. It is known that m6A methylation is involved in regulation, including gene expression, homeostasis, mRNA stability and other biological ...
Shaowei Fan, Yuanhui Hu
doaj +1 more source