Results 51 to 60 of about 26,139 (253)

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]

, 2017
Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven), Calderone, V. (Vittorio), Elkon, R. (Ran), Han, R. (Ruiqi), Loayza-Puch, F. (Fabricio), Slobodin, B. (Boris), Vrielink, J.A.F.O. (Joachim A.F. Oude)   +6 more
core   +4 more sources

Global profiling of N6‐methyladenosine methylation in maize callus induction

The Plant Genome, 2020
Callus induction is a dedifferentiation process that accompanies a cell fate transition, and epigenetic regulation plays a crucial role in the process.
Xuemei Du, Ting Fang, Yan Liu, Meng Wang, Maosen Zang, Liying Huang, Sihan Zhen, Jie Zhang, Zichen Shi, Guoying Wang, Junjie Fu, Yunjun Liu   +11 more
doaj   +1 more source

Research advances in m⁶A methylation and sepsis. [PDF]

Front Cell Dev Biol
Sepsis is an infection-induced syndrome driven primarily by dysregulated host inflammatory responses. This process induces complex physiological changes that provoke systemic inflammation and multi-organ dysfunction, severely threatening survival in advanced cases. N6-methyladenosine (m 6 A),
Zhang L, Chen W, Liu Y, Zhang S, Yin B, Liu K, Gu X, Hu X.   +7 more
europepmc   +2 more sources

Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants [PDF]

, 2016
13 p.-1 fig.Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs.
Del Mazo, Jesús, Larriba, E.
core   +2 more sources

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

The role of m6A RNA methylation in cancer

Biomedicine & Pharmacotherapy, 2019
N6-methyladenosine (m6A), the most abundant internal modification of RNA in eukaryotic cells, has gained increasing attention in recent years. The m6A modification affects multiple aspects of RNA metabolism, ranging from RNA processing, nuclear export, RNA translation to decay.
Ting, Sun, Ruiyan, Wu, Liang, Ming
openaire   +2 more sources

Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]

Open Biology, 2017
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang, Hongyi Lv, Weilong Zhang, Chunhui Ma, Xue He, Shunli Zhao, Zhi-Wei Zhang, Yi-Xin Zeng, Shuhui Song, Yamei Niu, Wei-Min Tong   +10 more
doaj   +1 more source

Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana [PDF]

, 2015
Proportion of two types of m6A distributing feature in mRNA.
Dayong Zhang, Kai Tang, Shaojun Xie, Xiaohong Zhu, Yizhen Wan, Zegang Wang, Zhaobo Lang   +6 more
core   +11 more sources

Review of the role and potential clinical value of m6A methylation modifications in the biological process of osteosarcoma

Frontiers in Genetics
Osteosarcoma (OS), an aggressive bone tumor, is a substantial threat to the quality of life and survival of affected individuals. Despite recent improvements in OS therapies, the considerable variability and chemotherapy resistance of this cancer ...
Huaqiang Zhou, Rongbing Shu, Jianming Wu, Jiangjun Zhou, Zhuanyi Yu, Qiuxin Cheng, Zhihao Peng, Min Zhao   +7 more
doaj   +1 more source

tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
core   +1 more source