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m6A modification: a novel mechanism that regulates atherosclerosis via macrophage polarization. [PDF]
Front ImmunolLi X, Zhang H, Zhou Y, Zhang L, Huang Y.
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Modulation of circRNA Metabolism by m6A Modification [PDF]
Cell Reports, 2020 N6-methyladenosine (m6A) is an RNA modification well-known for its contribution to different processes controlling RNA metabolism, including splicing, stability, and translation of mRNA. Conversely, the role of m6A on the biogenesis and function of circular RNAs (circRNAs) has yet to be addressed.
Alvaro Centrón-Broco +2 more
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N6‐methyladenosine (m6A) Modification in Preeclampsia
Reproductive Sciences, 2023Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang +6 more
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The role of m6A modification in pediatric cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022With the development of RNA modification research, the importance of N6-methyladenosine (m6A) in tumors cannot be ignored. m6A promotes the self-renewal of tumor stem cells and the proliferation of tumor cells. It affects post-transcriptional gene expression through epigenetic mechanisms, combining various factors to determine proteins' fate and ...
Yongping, Chen +4 more
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Exploring the role of m6A modification in cancer
PROTEOMICS, 2022Abstract m6A is one of the most common, abundant, and conserved post‐transcriptional modifications that regulate broad biological processes in the human body through m6A regulators. m6A regulators are figuratively classified according to their functions: writers, erasers, and readers, which can methylate RNAs, demethylate RNAs, and ...
Yongqi Wei, Yin Li, Chunlai Lu
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N6‐methyladenosine (m6A) modification in gynecological malignancies
Journal of Cellular Physiology, 2022AbstractN6‐methyladenosine (m6A) modification is one of the most abundant modifications in eukaryotic mRNA, regulated by m6A methyltransferase and demethylase. m6A modified RNA is specifically recognized and bound by m6A recognition proteins, which mediate splicing, maturation, exonucleation, degradation, and translation.
Chunmei Zhang, Ning Liu
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RNA m6A modification and its function in diseases [PDF]
Frontiers of Medicine, 2018 N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A "writers" composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A "erasers" (FTO and ALKBH5).
Jiyu Tong +2 more
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m6A Modification and Implications for microRNAs
MicroRNA, 2017RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes.Here, we review recent literature ...
Ayse Elif, Erson-Bensan, Oguzhan, Begik
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RNA m6A modifications in mammalian gametogenesis and pregnancy
Reproduction, 2022In brief RNA modifications play key roles in regulating various biological processes. This article discusses and summarizes the recent advances of RNA m6A modifications related to mammalian gametogenesis, early embryonic development, and miscarriage.
Xuesong Sui, Arne Klungland, Lu Gao
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