Results 211 to 220 of about 836,621 (308)

VIRMA modulates function of photoreceptor cells through m6A modification and alternative splicing. [PDF]

JCI Insight
Liu W, Wu X, Zou R, Zhang F, Fan Y, Sun K, Yang L, Hu J, Zhang L, Zhu X.   +9 more
europepmc   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Circ17399 RNA promotes melanoma progression through the miR-150-3p/ITM2C Axis and ALKBH5-mediated FOXM1 m6A modification. [PDF]

J Transl Med
Yang R, Wang X, Zhuo J, Tang L, Kang D, Liu S, Li J, Zhou S.   +7 more
europepmc   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma. [PDF]

J Pathol
Wang J, Hao Y, He M, Zhou W.
europepmc   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

METTL3-Mediated m6A Modification of lncRNA-0949 Drives Microglial Inflammation in an vitro Model of Sepsis-Associated Encephalopathy. [PDF]

J Inflamm Res
Zeng X, Luo XJ, Zhang ZZ, Lu JL, Zhan YA.   +4 more
europepmc   +1 more source

Circular RNAs in Drug‐Induced Cardiotoxicity: Roles, Mechanisms, and Therapeutic Potential

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Circular RNAs have emerged as novel regulators and potential biomarkers in drug‐induced cardiotoxicity. This review summarizes the biogenesis, functional roles, and translational potential of circRNAs in cardiotoxicity assessment and drug safety evaluation.
KeXin Leng, Zixuan Yang, Lei Shi, Zhimin Sun, Mengyun Gu, Naping Tang   +5 more
wiley   +1 more source