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The functional roles of m6A modification in prostate cancer
PROTEOMICS – Clinical Applications, 2023AbstractProstate cancer (PCa) is the most prevalent malignancy of the male genitourinary system, and its etiology suggests that genetics is an essential risk factor for its development and progression, while exogenous factors may have an significant impact on this risk.
Fa Zhang +3 more
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Regulation and functions of non-m6A mRNA modifications
Nature Reviews Molecular Cell Biology, 2023Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has resulted in the emergence of epitranscriptomics as a research field. The most abundant internal (non-cap) mRNA modification is N6-methyladenosine (m6A), the study of which has revolutionized our understanding of post-transcriptional gene regulation.
Hanxiao Sun +3 more
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m6A epitranscriptomic modification in diabetic microvascular complications
Trends in Pharmacological Sciences, 2023N6-methyladenosine (m6A) modifications are modulated by m6A methyltransferases, m6A demethylases, and m6A-binding proteins. The dynamic and reversible patterns of m6A modification control cell fate programming by regulating RNA splicing, translation, and decay.
Li-Chan Lin +4 more
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m6A mRNA modification regulates mammalian spermatogenesis
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N6-methyladenosine (m6A), an epitranscriptomic regulator of gene expression, can influence pre-mRNA splicing, mRNA export, turnover, and
Zhen, Lin, Ming-Han, Tong
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Advances in the profiling of N6-methyladenosine (m6A) modifications
Biotechnology Advances, 2020Over 160 RNA modifications have been identified, including N7-methylguanine (m7G), N6-methyladenosine (m6A), and 5-methylcytosine (m5C). These modifications play key roles in regulating the fate of RNA. In eukaryotes, m6A is the most abundant mRNA modification, accounting for over 80% of all RNA methylation modifications.
Hong-Xiang, Zheng +2 more
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The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming
Current Gene Therapy, 2023Abstract: As one of the main characteristics of neoplasia, metabolic reprogramming provides nutrition and energy to enhance cell proliferation and maintain environment homeostasis. Glycolysis is one of the most important components of cancer metabolism and the Warburg effect contributes to the competitive advantages of cancer cells in the threatened ...
Yuanqi, Li +5 more
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RNA m6A modification meets plant hormones
Nature PlantsPlant hormones are essential signalling molecules that control and coordinate diverse physiological processes in plant development and adaptation to ever-fluctuating environments. This hormonal regulation of plant development and environmental responses has recently been shown to extensively involve the most widespread RNA modification, N6 ...
Lisha Shen, Hao Yu
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m6A and beyond: RNA modifications shaping angiogenesis
Trends in Molecular MedicineRNA modifications are crucial post-transcriptional processes that significantly influence gene expression, RNA stability, nuclear transport, and translational capacity. Angiogenesis, the formation of new blood vessels, is a physiological process that is dysregulated in many pathological conditions, including ocular diseases, immune disorders, and ...
Yu, Luan +3 more
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m6A epitranscriptomic modification of inflammation in cardiovascular disease
International ImmunopharmacologyCardiovascular disease is currently the number one cause of death endangering human health. There is currently a large body of research showing that the development of cardiovascular disease and its complications is often accompanied by inflammatory processes.
Yun-Sen Zhang +6 more
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Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis
2022Apoptosis is a form of programmed cell death that is essential for cellular and organismal homeostasis. Any irregularities that disturb the balance between apoptosis and cell survival have severe implications, such as improper development or life-threatening diseases.
Azime, Akçaöz, Bünyamin, Akgül
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