Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets [PDF]
MedCommCell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long +5 more
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A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease [PDF]
Advances in Respiratory MedicineHuman airways maintain homeostasis through intricate cellular interactomes combining secretome-mediated signalling and mechanotransduction feedback loops.
Crizaldy Tugade, Jopeth Ramis
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Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments [PDF]
Materials Today BioOrganoid morphogenesis is orchestrated by complex mechanical interactions between cells and their microenvironment. Recent evidence highlights the critical role of mechanical stimuli—including fluid shear stress, axial tensile and compressive forces ...
Xinxin Zhang +4 more
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The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives [PDF]
Frontiers in ImmunologyOrgan fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function.
Chao Lei +7 more
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A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes
Biophysical Reports, 2021 Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
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LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function
Frontiers in Cell and Developmental Biology, 2021 Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
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Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
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Substrate stiffness controls proinflammatory responses in human gingival fibroblasts
Scientific Reports, 2023 Soft gingiva is often compromised in gingival health; however, the underlying biological mechanisms remain unknown. Extracellular matrix (ECM) stiffness is involved in the progression of various fibroblast-related inflammatory disorders via cellular ...
Watcharaphol Tiskratok +5 more
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Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction
Cell Death and Disease, 2022 Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator of cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development and treatment. However, the
Lijun Zheng +15 more
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Cells, 2022 In this review, we shed light on recent advances regarding the characterization of biochemical pathways of cellular mechanosensing and mechanotransduction with particular attention to their role in neurodegenerative disease pathogenesis.
Ilaria Tortorella +4 more
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