Results 11 to 20 of about 22,933 (258)

Biophysical Tools to Study Cellular Mechanotransduction [PDF]

Bioengineering, 2017
The cell membrane is the interface that volumetrically isolates cellular components from the cell’s environment. Proteins embedded within and on the membrane have varied biological functions: reception of external biochemical signals, as membrane ...
Ismaeel Muhamed, Farhan Chowdhury, Venkat Maruthamuthu   +2 more
doaj   +4 more sources

Cellular Mechanotransduction: From Tension to Function [PDF]

Frontiers in Physiology, 2018
Living cells are constantly exposed to mechanical stimuli arising from the surrounding extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes through which such physical cues are transformed into a biological response
Fabiana Martino, Fabiana Martino, Fabiana Martino, Ana R. Perestrelo, Vladimír Vinarský, Vladimír Vinarský, Stefania Pagliari, Giancarlo Forte, Giancarlo Forte, Giancarlo Forte   +9 more
doaj   +4 more sources

Optogenetic control of cellular forces and mechanotransduction [PDF]

Nature Communications, 2017
Cellular mechanical forces are regulated by Rho GTPases. Here the authors develop an optogenetic system to control the spatiotemporal activity of RhoA, and show that directing a RhoA activator to the plasma membrane causes contraction and YAP nuclear ...
Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras, Xavier Trepat   +4 more
doaj   +5 more sources

Cellular mechanotransduction of human osteoblasts in microgravity

npj Microgravity
Astronauts experience significant and rapid bone loss as a result of an extended stay in space, making the International Space Station (ISS) the perfect laboratory for studying osteoporosis due to the accelerated nature of bone loss on the ISS.
Nadab H. Wubshet, Grace Cai, Samuel J. Chen, Molly Sullivan, Mark Reeves, David Mays, Morgan Harrison, Paul Varnado, Benjamin Yang, Esmeralda Arreguin-Martinez, Yunjia Qu, Shan-Shan Lin, Pamela Duran, Carlos Aguilar, Shelby Giza, Twyman Clements, Allen P. Liu   +16 more
doaj   +4 more sources

Cellular responses to beating hydrogels to investigate mechanotransduction [PDF]

Nature Communications, 2019
Mechanotransduction of cells is of interest for a number of reasons but model in vitro systems remain a challenge. Here, the authors report on a hydrogel which changes properties upon near infrared irradiation to create cyclic forces and demonstrate the ...
Yashoda Chandorkar, Arturo Castro Nava, Sjören Schweizerhof, Marcel Van Dongen, Tamás Haraszti, Jens Köhler, Hang Zhang, Reinhard Windoffer, Ahmed Mourran, Martin Möller, Laura De Laporte   +10 more
doaj   +3 more sources

The energetics of rapid cellular mechanotransduction

Proceedings of the National Academy of Sciences, 2022
Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as sensors of mechanical energy is still lacking.
Michael N. Young, Michael J. Sindoni, Amanda H. Lewis, Stefan Zauscher, Jörg Grandl   +4 more
openaire   +2 more sources

Effect of aging on cellular mechanotransduction [PDF]

Ageing Research Reviews, 2011
Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation ...
Miaozong, Wu, Jacqueline, Fannin, Kevin M, Rice, Bin, Wang, Eric R, Blough   +4 more
openaire   +2 more sources

Cellular mechanotransduction

AIMS Biophysics, 2016
Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions.  Adherent cells are anchored via focal adhesions ...
Wolfgang H. Goldmann, José Luis Alonso
openaire   +2 more sources

Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]

PLoS Genetics, 2010
Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore, Vatrapu Rami Reddy, Michel Sémériva, Laurent Perrin, Nathalie Lalevée   +4 more
doaj   +1 more source

Dynamic molecular processes mediate cellular mechanotransduction [PDF]

Nature, 2011
Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion ...
Brenton D, Hoffman, Carsten, Grashoff, Martin A, Schwartz   +2 more
openaire   +2 more sources