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Review of cellular mechanotransduction [PDF]
Journal of Physics D: Applied Physics, 2017 Living cells and tissues experience physical forces and chemical stimuli in a human body. The process of converting mechanical forces into biochemical activities and gene expression is mechanochemical transduction or mechanotransduction. Significant advances have been made in understanding mechanotransduction at cellular and molecular levels over the ...
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Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2010 Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression ...
Wang James HC, Li Bin
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Pharmaceuticals, 2020 Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues.
Adam Frtús +12 more
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Mechanosignals in abdominal aortic aneurysms
Frontiers in Cardiovascular Medicine, 2023 Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA).
Christiana Lowis +14 more
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Control of cell differentiation by mechanical stress
Journal of Physical Fitness and Sports Medicine, 2013 Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing ...
Jong-Hoon Park +2 more
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Cellular Mechanosensitivity: Validation of an Adaptable 3D-Printed Device for Microindentation
Nanomaterials, 2022 Mechanotransduction refers to the cellular ability to sense mechanical stimuli from the surrounding environment and convert them into biochemical signals that regulate cellular physiology and homeostasis.
Giulio Capponi +7 more
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Traction Force Microscopy for Understanding Cellular Mechanotransduction
BMB Reports, 2020 Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors.
Hur, Sung Sik +5 more
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Talin Folding as the Tuning Fork of Cellular Mechanotransduction [PDF]
Proceedings of the National Academy of Sciences, 2020 Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics of force-sensing proteins have only been tested using
Tapia-Rojo, Rafael +2 more
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High-throughput optical screening of cellular mechanotransduction [PDF]
Nature Photonics, 2014 We introduce an optical platform for rapid, high-throughput screening of exogenous molecules that affect cellular mechanotransduction. Our method initiates mechanotransduction in adherent cells using single laser-microbeam generated micro-cavitation bubbles (μCBs) without requiring flow chambers or microfluidics.
Compton, JL +4 more
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Cell Mechanotransduction With Piconewton Forces Applied by Optical Tweezers
Frontiers in Cellular Neuroscience, 2018 Mechanical stresses are always present in the cellular environment and mechanotransduction occurs in all cells. Although many experimental approaches have been developed to investigate mechanotransduction, the physical properties of the mechanical ...
Fabio Falleroni +4 more
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