Results 31 to 40 of about 22,933 (258)

Biomimetic substrate control of cellular mechanotransduction

Biomaterials Research, 2016
Abstract Extracellular mechanophysical signals from both static substrate cue and dynamic mechanical loading have strong potential to regulate cell functions. Most of the studies have adopted either static or dynamic cue and shown that each cue can regulate cell adhesion, spreading, migration, proliferation, lineage commitment, and ...
Andalib, Mohammad Nahid, Dzenis, Yuris A, Donahue, Henry J., Lim, Jung Yul   +3 more
openaire   +2 more sources

Talin‑1 interaction network in cellular mechanotransduction (Review)

International Journal of Molecular Medicine, 2022
The mechanical signals within the extracellular matrix (ECM) regulate cell growth, proliferation and differentiation, and integrins function as the hub between the ECM and cellular actin. Focal adhesions (FAs) are multi‑protein, integrin‑containing complexes, acting as tension‑sensing anchoring points that bond cells to the extracellular ...
Zhao, Ye, Lykov, Nikita, Tzeng, Chimeng
openaire   +2 more sources

3D Cell Culture for the Study of Microenvironment-Mediated Mechanostimuli to the Cell Nucleus: An Important Step for Cancer Research

Frontiers in Molecular Biosciences, 2021
The discovery that the stiffness of the tumor microenvironment (TME) changes during cancer progression motivated the development of cell culture involving extracellular mechanostimuli, with the intent of identifying mechanotransduction mechanisms that ...
Apekshya Chhetri, Apekshya Chhetri, Joseph V. Rispoli, Joseph V. Rispoli, Sophie A. Lelièvre, Sophie A. Lelièvre   +5 more
doaj   +1 more source

Gold-tipped elastomeric pillars for cellular mechanotransduction [PDF]

Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena, 2009
The authors describe a technique for the fabrication of arrays of elastomeric pillars whose top surfaces are treated with selective chemical functionalization to promote cellular adhesion in cellular force transduction experiments. The technique involves the creation of a rigid mold consisting of arrays of circular holes into which a thin layer of Au ...
S, Ghassemi, O, Rossier, M P, Sheetz, S J, Wind, J, Hone   +4 more
openaire   +2 more sources

A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures

Frontiers in Psychology, 2022
The primary aim of this article is to provide a biological rhythm model based on previous theoretical and experimental findings to promote more comprehensive studies of rhythmic mechanical stimulation of cell cultures, which relates to tissue engineering
Dongho Kwak, Petter Angell Olsen, Petter Angell Olsen, Anne Danielsen, Alexander Refsum Jensenius   +4 more
doaj   +1 more source

Flow-dependent cellular mechanotransduction in atherosclerosis

Journal of Cell Science, 2013
Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex changes in speed and direction.
Daniel E, Conway, Martin A, Schwartz
openaire   +3 more sources

A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes [PDF]

European Cells & Materials, 2010
Mechanical forces are translated into biochemical signals and contribute to cell differentiation and phenotype maintenance. Mesenchymal stem cells and their tissue-specific offspring, as osteoblasts and chondrocytes, cells of cardiovascular tissues and ...
W Wilke, F Jakob, R Ebert, A Ignatius, M Schieker, L Claes, D Docheva, A Liedert, M Kassem, T Lind, B Mentrup, M Kober, T Schwarz, S Mueller-Deubert, L Seefried   +14 more
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease

Frontiers in Cell and Developmental Biology, 2020
Phosphoinositides, which are membrane-bound phospholipids, are critical signaling molecules located at the interface between the extracellular matrix, cell membrane, and cytoskeleton.
Amanda Krajnik, Joseph A. Brazzo, Kalyanaraman Vaidyanathan, Tuhin Das, Javier Redondo-Muñoz, Javier Redondo-Muñoz, Yongho Bae   +6 more
doaj   +1 more source

GTPase-Dependent Mechanointegration of Shear-Mediated Cell Contractility Through Dynamic Binding of FLNa and FilGAP

Frontiers in Physics, 2022
Cellular mechanotransduction is a common mechanism by which cells convert mechanical cues (or stimuli) from their environment into biochemical and cellular responses.
L. P. Bergeron-Sandoval, Alex Cai, Alex Cai, Anna Clouvel, Cynthia Hitti, Allen Ehrlicher, Allen Ehrlicher, Allen Ehrlicher, Allen Ehrlicher, Allen Ehrlicher   +9 more
doaj   +1 more source