Results 41 to 50 of about 22,933 (258)

Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

APL Bioengineering
Mechanotransduction regulates cytoskeletal remodeling, nuclear mechanics, and metabolic adaptation, which are central to cellular aging and rejuvenation.
Hye-Min Han, Su-Yeon Kim, Dong-Hwee Kim
doaj   +1 more source

Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction

Frontiers in Bioengineering and Biotechnology, 2021
Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state.
Fabrizio A. Pennacchio, Paulina Nastały, Paulina Nastały, Alessandro Poli, Paolo Maiuri   +4 more
doaj   +1 more source

Role of Integrin in Cellular Mechanotransduction [PDF]

Biophysical Journal, 2013
Chemical and physical cues from the extracellular matrix (ECM) are used as input for an integrated mechanochemical sensory system that controls cell behavior. Forces derived from the ECM have been implicated in various biological systems, including mesenchymal stem cell differentiation and tumor growth.
Balcioglu, H.E., Danen, E.H.J.
openaire   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

New insights into Wnt - Lrp5/6 - β-catenin signaling in mechanotransduction

Frontiers in Endocrinology, 2015
Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Alexander eRobling, Kyung Shin eKang
doaj   +1 more source

Revealing hidden information in osteoblast’s mechanotransduction through analysis of time patterns of critical events

BMC Bioinformatics, 2020
Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani, Timothy M. Skerry, Damien Lacroix, Enrico Dall’Ara, Aban Shuaib   +4 more
doaj   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Role of Mechanotransduction in Cellular Processes [PDF]

Biophysical Journal, 2009
The role of mechanical properties of cells is gaining increasing attention due to the regulatory role that it plays in cellular processes. In particular the transduction of an applied force on the cell membrane through the cellular components can have significant influence on such phenomena as stochasticity in gene expression and cancer metastasis.
Srividya, Narayanan, Balandaram, Gayathri, Bandaranayake, Chandima, Muralidharan, Subra   +3 more
openaire   +1 more source

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source