Results 51 to 60 of about 22,933 (258)

Mechanotransduction mechanisms in growing spherically structured tissues

New Journal of Physics, 2018
There is increasing experimental interest in mechanotransduction in multi-cellular tissues as opposed to single cells. This is driven by a growing awareness of the importance of physiologically relevant three-dimensional culture and of cell–cell and cell–
Euan Littlejohns, Carina M. Dunlop
doaj   +1 more source

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Cells, 2023
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction
Laura Sotodosos-Alonso, Marta Pulgarín-Alfaro, Miguel A. del Pozo   +2 more
doaj   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Osteocyte: a Cellular Basis for Mechanotransduction in Bone

Journal of Biomechanical Science and Engineering, 2007
Osteocyte is the most abundant cell type in bone, and the only cell type located inside the mineralized matrix. The striking structural design of bone predicts an important role for osteocytes in determining bone structure and function.
Guoliang GU, Kosaku KURATA, Zhi CHEN, Kalervo H. VÄÄNÄNEN   +3 more
doaj   +1 more source

In vivo mechanotransduction: Effect of acute exercise on the metabolomic profiles of mouse synovial fluid

Osteoarthritis and Cartilage Open, 2022
Objective: Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated mechanical loading during exercise.
Alyssa K. Hahn, Rachel A. Rawle, Brian Bothner, Erika Barboza Prado Lopes, Timothy M. Griffin, Ronald K. June   +5 more
doaj   +1 more source

The Cellular Mastermind(?)—Mechanotransduction and the Nucleus [PDF]

, 2014
Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation.
Ashley, Kaminski, Gregory R, Fedorchak, Jan, Lammerding   +2 more
openaire   +2 more sources

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Mechanotransducing Organic Electrochemical Diode for Crosstalk‐Inhibited Artificial Skin

Advanced Functional Materials, EarlyView.
An innovative approach is presented to a stretchable mechanotransducing diode that unifies rectification and tactile‐sensing functionality. This approach enables to fabricate the diode that maintains a large rectification ratio (5 × 102) at a high operational frequency (100 Hz).
Taeyeong Kim, Seunggoo Baek, Garrett Lecroy, Hyeongseok Choi, Wonjeong Suh, Woosung Cho, Alberto Salleo, Unyong Jeong   +7 more
wiley   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Model of cellular mechanotransduction via actin stress fibers [PDF]

Biomechanics and Modeling in Mechanobiology, 2015
Mechanical stresses due to blood flow regulate vascular endothelial cell structure and function and play a key role in arterial physiology and pathology. In particular, the development of atherosclerosis has been shown to correlate with regions of disturbed blood flow where endothelial cells are round and have a randomly organized cytoskeleton.
Gouget, CLM, Hwang, Y, Barakat, AI
openaire   +4 more sources