Results 91 to 100 of about 18,845 (218)

Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology

Molecules, 2015
Melanin is a natural pigment that plays an important role in the protection of skin, however, hyperpigmentation cause by excessive levels of melatonin is associated with several problems.
Ji Yeon Jeong, Qing Liu, Seon Beom Kim, Yang Hee Jo, Eun Jin Mo, Hyo Hee Yang, Dae Hye Song, Bang Yeon Hwang, Mi Kyeong Lee   +8 more
doaj   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

The Cutaneous Melatoninergic System: Endogenous Biology and Potential for Therapeutic Targeting

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Melatonin is best known as a pineal hormone that regulates circadian rhythms, but the skin also possesses an intrinsic melatoninergic system capable of local synthesis, metabolism and signalling. This system encompasses classical melatonin receptors, biologically active metabolites, non‐classical signalling pathways and receptor‐independent ...
Ju Hee Han, Hei Sung Kim
wiley   +1 more source

Screening of Key Components for Melanogenesis Inhibition of Polygonum cuspidatum Extract Based on the Spectrum–Effect Relationship and Molecular Docking

Molecules
Polygonum cuspidatum (PC) extract has been listed in the “Catalog of Used Cosmetic Ingredients (2021 Edition)”, which can inhibit melanogenesis, thus exerting a whitening effect, and has been widely used in cosmetics.
Ruojun Du, Lichun Ye, Xinyan Chen, Yan Meng, Lei Zhou, Qiao Chen, Guohua Zheng, Junjie Hu, Zhaohua Shi   +8 more
doaj   +1 more source

Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer, Peter Emerson, Matthew Bodnar, Thomas Jones, David R. Russell, Matthew Pehrson, Cheyenne R. Smith, Danielle Cleveland, Mark J. Henderson, Patricia M. Mazik   +9 more
wiley   +1 more source

Comparison of ball python and Burmese python genomic and protein sequences for melanogenesis genes.

, 2022
Comparison of ball python and Burmese python genomic and protein sequences for melanogenesis genes.
Hunter C. Meyers (13982916), Haily McCullough (13982910), Yamini Donekal (13982913), Dominic Mannino (13982907), Hannah S. Seidel (13982922), Autumn R. Brown (13982901), Chiron W. Graves (13982919), Kaylee Comai (13982904)   +7 more
core   +1 more source

Co-Treatment with Phlorotannin and Extracellular Vesicles from Ecklonia cava Inhibits UV-Induced Melanogenesis

Antioxidants
Hyperpigmentation due to ultraviolet (UV)-induced melanogenesis causes various esthetic problems. Phlorotannin (PT) and extracellular vesicles (EVs) derived from various plants suppress melanogenesis pathways.
Kyung-A Byun, Youngjin Park, Seyeon Oh, Sosorburam Batsukh, Kuk Hui Son, Kyunghee Byun   +5 more
doaj   +1 more source

ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1.

PLoS ONE, 2013
Melanosomes are lysosome-related organelles that serve as specialized sites of melanin synthesis and storage in melanocytes. The progression of melanosomes through the different stages of their formation requires trafficking of specific proteins and ...
Eyal Kalie, Minoo Razi, Sharon A Tooze
doaj   +1 more source

Beyond Pigmentation: Dermoscopic Vascular Patterns Reveal Novel Risk and Protective Factors in Melasma

Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.
ABSTRACT Objective To investigate the correlation between the dermoscopic severity of telangiectasia and key pathophysiological features in melasma, and to identify the risk factors associated with vascular pattern severity. Methods In this cross‐sectional study, 137 female melasma patients were classified into four vascular types based on dermoscopic ...
Zhenghui Yang, Jing Wu, Qiuyan Yao, Hua Gu, Ying Tu   +4 more
wiley   +1 more source

Stimulation of melanogenesis by scoparone in B16 melanoma cells

, 2006
Aim: The effect of coumarin derivatives on melanogenesis was investigated in B16 murine melanoma cells. Methods: Melanin content and tyrosinase activity were analyzed spectrophotometrically. The expression of tyrosinase, tyrosinase-related protein-1 (TRP-
Eun-chung JHEE, Song, Young-gil, Hee-sook SOHN, Koo, Jeung-hyun, Jeung-hyun KOO, Kang-beom KWON, Park, Jin-woo, Jhee, Eun-chung, Ju-hyung LEE, Lee, Ju-hyung, Jeong-yeh YANG, Young-gil SONG, Byung-hyun PARK, Park, Byung-hyun, Kwon, Kang-beom, Yang, Jeong-yeh, Sohn, Hee-sook, Jin-woo PARK   +17 more
core   +1 more source