Results 61 to 70 of about 26,405 (229)

ENZYME LOCALIZATION DURING MELANOGENESIS [PDF]

The Journal of Cell Biology, 1969
The DOPA-reaction was used to identify tyrosinase in the nucleus and cytoplasm of the neural crest melanoblast of Taricha torosa, the California newt. In this urodele there is a nuclear DOPA-positive response during the normal embryonic development from the late blastula stage to the nucleus of the early melanocyte.
openaire   +2 more sources

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Goras Georgios, Thrasyvoulou Andreas, Tsilimpokou Evanthia   +2 more
wiley   +1 more source

Haplotype differences for copy number variants in the 22q11.23 region among human populations: a pigmentation-based model for selective pressure. [PDF]

, 2014
Two gene clusters are tightly linked in a narrow region of chromosome 22q11.23: the macrophage migration inhibitory factor (MIF) gene family and the glutathione S-transferase theta class.
A Enomoto, Andrea Iorio, Andrea Novelletto, Andrey Kozlov, B Sonesson, CD Campbell, CF Thorn, DH O'Rourke, DJ Tobin, DM Altshuler, F Luca, F Zhang, Flavio De Angelis, GF De Stefano, GR Abecasis, GS Barsh, H Watanabe, HL Norton, J Du, JC Barrett, KE Lohmueller, L Excoffier, M Bozza, M Coggan, M Merk, M Merk, Maria Fuciarelli, MD Shriver, MG Parisi, NE Savaskan, NG Jablonski, NG Jablonski, OP Pietilainen, R Biasutti, R Polimanti, R Polimanti, R Polimanti, RA Sturm, RC Iskow, RE Mills, Renato Polimanti, S Girirajan, S Piacentini, S Ramachandran, SA McCarroll, SA McCarroll, Sara Piacentini, SI Candille, T Hofer, T Shimizu, T Shimizu, Y Zhao   +51 more
core   +1 more source

Effectiveness and Safety of Setmelanotide in a Patient With a Heterozygous PCSK1 Deficiency

Obesity, EarlyView.
ABSTRACT Setmelanotide, a melanocortin 4 receptor (MC4R) agonist, is a promising pharmacological treatment option for people with rare monogenic obesity conditions affecting the leptin‐melanocortin signaling pathway, including proprotein convertase subtilisin/kexin type 1 (PCSK1) gene mutations.
Ellina Lytvyak, Arshdeep Rattol, Eduardo Grunvald   +2 more
wiley   +1 more source

Dynamics of Melanogenesis Intermediates.

Journal of Investigative Dermatology, 1993
The course of melanogenesis in (malignant) melanocytes is determined by several relatively independent metabolic processes such as tyrosine uptake and compartmentation, the activity of tyrosinase, and the capacity of melanosomes to produce and store melanin. There is experimental evidence that tyrosine is transported across the cell membrane with a Na(+
openaire   +2 more sources

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. [PDF]

, 2017
PurposeThe RPE cell line ARPE-19 provides a dependable and widely used alternative to native RPE. However, replication of the native RPE phenotype becomes more difficult because these cells lose their specialized phenotype after multiple passages ...
Duncan, Todd, Jaworski, Cynthia, Kutty, R Krishnan, Lakkaraju, Aparna, Poliakov, Eugenia, Postnikova, Olga A, Redmond, T Michael, Samuel, William, Tan, Li Xuan   +8 more
core   +2 more sources

Condition-dependence, pleiotropy and the handicap principle of sexual selection in melanin-based colouration. [PDF]

, 2015
The signalling function of melanin-based colouration is debated. Sexual selection theory states that ornaments should be costly to produce, maintain, wear or display to signal quality honestly to potential mates or competitors.
Roulin, A.
core   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

Melanogenesis inhibition by tetrahydropterines

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2009
There is controversy in the literature concerning the action of tetrahydropterines on the enzyme tyrosinase and on melanogenesis in general. In this study, we demonstrate that tetrahydropterines can inhibit melanogenesis in several ways: i) by non-enzymatic inhibition involving purely chemical reactions reducing o-dopaquinone to L-dopa, ii) by acting ...
García Molina, Francisco, Muñoz Muñoz, Jose Luis, Acosta Motos, José Ramón, García Ruíz, Pedro Antonio, Tudela, Jose, García Cánovas, Francisco, Rodríguez López, José Neptuno   +6 more
openaire   +3 more sources