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Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host [PDF]
Gut MicrobesMetabolic diseases pose a major global health challenge, the pathogenesis of which centers on “metabolic reprogramming”; that is, the adaptive or pathological rewiring of metabolic pathways.
Yanrong Wang +6 more
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BMC Medical Genomics, 2023 Background Colorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the mechanism by which Jatrorrhizine (JAT), a root extract from Stephania Epigaea Lo, exerts its anticancer ...
Lingyu Huang +8 more
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Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
Viruses, 2022 Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for large-scale biosynthesis. Based on studies of the cellular changes that contribute to
Charles N. S. Allen +3 more
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Metabolic Reprogramming in Kidney Diseases: Evidence and Therapeutic Opportunities
International Journal of Nephrology, 2021 Metabolic reprogramming originally referred to the ability of cancer cells to metabolically adapt to changes in environmental conditions to meet both energy consumption and proliferation requirements.
Yin Li, Zixin Sha, Hui Peng
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Frontiers in Oncology, 2022 Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells.
Shushan Yan +8 more
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International Journal of Hyperthermia, 2023 Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing ...
Yuchuan Yang +3 more
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Cancer & Metabolism, 2019 Background Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival.
Sheree D. Martin, Sean L. McGee
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Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease
Frontiers in Immunology, 2022 Macrophages are highly plastic cells, and the polarization-activating actions that represent their functional focus are closely related to metabolic reprogramming.
Xiaoqian Sun +12 more
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Metabolic reprogramming in cancer: Mechanisms and therapeutics
MedComm, 2023 Cancer cells characterized by uncontrolled growth and proliferation require altered metabolic processes to maintain this characteristic. Metabolic reprogramming is a process mediated by various factors, including oncogenes, tumor suppressor genes ...
Shiqi Nong +9 more
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Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases
Redox Biology, 2023 Oxygen therapy is common during the neonatal period to improve survival, but it can increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in newborns, commonly causing lung conditions such as bronchopulmonary dysplasia ...
Tong Sun +4 more
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