Results 31 to 40 of about 109,926 (267)

Metabolic Reprogramming in Dietary Restriction [PDF]

, 2006
It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed.
Rozalyn M, Anderson, Richard, Weindruch
openaire   +2 more sources

Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis

Metabolites, 2021
Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and ...
Kenji Ohshima, Eiichi Morii
doaj   +1 more source

Metabolic reprogramming during neuronal differentiation [PDF]

Cell Death & Differentiation, 2016
Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic neurons undergo neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity.
Agostini M., Romeo F., Inoue S., Niklison-Chirou M. V., Elia A. J., Dinsdale D., Morone N., Knight R. A., Mak T. W., Melino G.   +9 more
openaire   +3 more sources

Metabolic Reprogramming Promotes Myogenesis During Aging [PDF]

Frontiers in Physiology, 2019
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging.
Roberta Belli, Agnese Bonato, Luciana De Angelis, Simone Mirabilii, Maria Rosaria Ricciardi, Agostino Tafuri, Alessio Molfino, Massimiliano Leigheb, Paola Costelli, Maurizia Caruso, Maurizio Muscaritoli, Elisabetta Ferraro, Elisabetta Ferraro   +12 more
openaire   +6 more sources

Nrf2‐Mediated Metabolic Reprogramming in Cancer [PDF]

Oxidative Medicine and Cellular Longevity, 2018
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2‐mediated cancer metabolic reprogramming and intend to highlight ...
Yan-Yang Wang, Juan Chen, Xiao-Ming Liu, Ren Zhao, Hong Zhe   +4 more
openaire   +2 more sources

The role of programmed cell death 1 in autoimmune diseases: mechanisms and therapeutic implications

Frontiers in Immunology
Autoimmune diseases are complex disorders caused by the interaction between the immune system and self-antigens, involving genetic, environmental triggers, and other cellular factors. The programmed cell death receptor-1 (PD-1) gene, as a critical factor
Zhenyu Liu, Zhenyu Liu, Zipeng Hu, Huilin Lao, Lemin Chen, Yue Wen, Yuqiang Liang, Chong Zhang, Jiang Wu, Xianliang Hou, Xianliang Hou   +10 more
doaj   +1 more source

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

Frontiers in Pharmacology, 2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC.
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu   +3 more
doaj   +1 more source

Metabolic reprogramming in osteoclasts

Seminars in Immunopathology, 2019
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of the bone. Defects in osteoclasts thus result in unbalanced bone remodeling, leading to numerous pathological conditions such as osteoporosis, bone metastasis, and inflammatory bone erosion.
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Construction of a Dataset for All Expressed Transcripts for Alzheimer’s Disease Research

Brain Sciences
Accurate identification and functional annotation of splicing isoforms and non-coding RNAs (lncRNAs), alongside full-length protein-encoding transcripts, are critical for understanding gene (mis)regulation and metabolic reprogramming in Alzheimer’s ...
Zhenyu Huang, Bocheng Shi, Xuechen Mu, Siyu Qiao, Gangyi Xiao, Yan Wang, Ying Xu   +6 more
doaj   +1 more source