Results 131 to 140 of about 21,239 (181)

Lidamycin induces mitophagy in pancreatic cancer cells by regulating the expression of Mfn2

Scientific Reports
Lidamycin (LDM) has been confirmed to have a strong anti-pancreatic cancer effect and can affect the mitochondrial function of pancreatic cancer cells. Mitofusin-2 (Mfn2) is located in the outer membrane of mitochondria, and Mfn2 is currently believed to
Boya Wu, Bing Qi, Liumeng Duan, Jing Chen   +3 more
doaj   +1 more source

Metabolic Diseases: a differential diagnosis of primary progressive multiple sclerosis [PDF]

, 2019
Objectives: The overall aim of our research project is to develop a Next Generation Sequencing strategy to identify metabolic disorders in 104 patients with a presumptive diagnosis of primary progressive MS.We would like to thank to MERCK, SA and ...
Macário, Maria do Carmo, Nogueira, Célia, Ribeiro, Diogo, Silva, Ana, Sá, Maria José, Vilarinho, Laura   +5 more
core  

Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription. [PDF]

Cell Death Dis
Liu Y, Wang N, Li Z, Li N, Hui F, Wang X, Tang G, Zhang Q, Yu G, Liu S, Ding Y.   +10 more
europepmc   +1 more source

Mitofusin MFN2 acts as a molecular sensor preventing protein aggregation and mitophagy, with a protective effect against apoptosis in Charcot-Marie-Tooth type 2A disease. [PDF]

Autophagy Rep
Joaquim M, Dohrn MF, Chevrollier A, Escobar-Henriques M.   +3 more
europepmc   +1 more source

Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction. [PDF]

Cell Discov
Zhao YY, Wang YH, Li ZH, Chang DY, Nie L, Zhao MH, Tang SCW, Chen M.   +7 more
europepmc   +1 more source

ZEB1 maintains mitochondrial fission and macrophage efferocytosis by restraining MFN2, thereby limiting inflammation and improving tendon‑bone healing. [PDF]

Int J Mol Med
Zhao Y, Zhang Y, Lei T, Zhang S, Nan K, Zhang X, Fan LH.   +6 more
europepmc   +1 more source

Targeting NME3 to Restore Mitochondrial Fission-Fusion Balance Defines a Novel Disease-Modifying Strategy for Parkinson's Disease. [PDF]

CNS Neurosci Ther
Qiao C, Hu XQ, Xu SH, Yao MF, Liu JP, Cao L.   +5 more
europepmc   +1 more source

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis. [PDF]

Cell Death Dis
Liu B, Liang Y, Wang C, Weng Z, Yang Y, Shi Y, Zhang C.   +6 more
europepmc   +1 more source

Bridging tradition and modernity: mitochondrial dynamics as a Traditional Chinese Medicine therapeutic target in cardiovascular disease. [PDF]

Chin Med
Du C, Yu Y, Li M, Zhou J, Wang Y, Guo X, Zhang H, Li Z, Han Y, Pang M, Yu R.   +10 more
europepmc   +1 more source

Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2. [PDF]

Animal Model Exp Med
Zhou X, Zhang Y, Ma H, Fu S, Liu J, Guo W, Tian X, Huang B.   +7 more
europepmc   +1 more source