miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression. [PDF]
EBioMedicine, 2018 Background: Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated to play a role in tumor initiation, development, and progression ...
Chen M +10 more
europepmc +5 more sources
Mol CancerHepatocellular carcinoma (HCC) is a major global health concern, necessitating innovative therapeutic strategies. In this study, we investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications.
Li H +9 more
europepmc +4 more sources
miR-590–5p: A double-edged sword in the oncogenesis process
Cancer Treatment and Research Communications, 2022 Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a ...
Tushar Singh Barwal +12 more
doaj +3 more sources
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p. [PDF]
NPJ Precis OncolN6-methyladenosine (m6A) has been established as a critical regulator in various human cancers. However, the role of m6A modification in renal cell carcinoma (RCC) and its interaction with long non-coding RNA LHX1-DT (LHX1-DT) remains unclear ...
Zhu C +7 more
europepmc +2 more sources
Cell Journal, 2016 Objective: SMAD proteins are the core players of the transforming growth factor-beta (TGFβ) signaling pathway, a pathway which is involved in cell proliferation, differentiation and migration.
Meisam Jafarzadeh, Bahram M. Soltani
doaj +3 more sources
hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis. [PDF]
Aging (Albany NY), 2023 Glioma is a general neurological tumor and circular RNAs (circRNAs) have been implicated in glioma development. However, the underlying mechanisms and circRNA biological functions responsible for the regulation of glioma progression remain unknown. In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in ...
Wu Z, Guan Q.
europepmc +3 more sources
Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. [PDF]
World J Gastrointest Oncol, 2023 As reported, multiple circular RNAs (circRNAs) interfere with colorectal cancer (CRC) progression. Here, circRNA_0001658 (circ_0001658) is focused on studying how it works in CRC.Clarify the expression pattern, biological function, and underlying mechanism of circ_0001658 of CRC tumorigenesis.In CRC-related chip data retrieved using the database named ...
Lu Y, Wang XM, Li ZS, Wu AJ, Cheng WX.
europepmc +3 more sources
miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. [PDF]
Oncol Lett, 2021 Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform.
Chen S +13 more
europepmc +4 more sources
miR-590-5p Targets Skp2 to Inhibit the Growth and Invasion of Malignant Melanoma Cells. [PDF]
Dis Markers, 2022 Skp2 participates in the regulation of cell growth cycle and promotes the growth of tumor cells. It was speculated that miR-590-5p could regulate the expression of Skp2 and have therapeutic effects on malignant melanin. In this study, the expression of Skp2 was detected by qRT-PCR and Western blot (WB), and the targeted binding between miR-590-5p and ...
Tong Y, Jin L.
europepmc +3 more sources
Integrative bioinformatic and clinical validation reveals dynamic regulation of circulating microRNAs before and after antiretroviral therapy in HIV-positive patients. [PDF]
Sci RepMicroRNAs (miRNAs) play a crucial role in gene regulation, including HIV, where they influence viral replication and immune response. This study aims to identify key miRNAs involved in HIV pathogenesis, using bioinformatics and cohort validation to ...
Sonmez H +8 more
europepmc +2 more sources