miR-590-5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]
Exp Ther Med, 2020 Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of colorectal cancer (CRC); however, the roles of miR-590-5p in CRC are not completely understood. Therefore, the present study investigated the expression of miR-590-5p and programmed cell death 4 (PDCD4) in CRC tissues and healthy adjacent tissues via reverse ...
Guo T, Wang J, Cheng G, Huang H.
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Downregulation of Circ-PITHD1 Suppressed Colorectal Cancer via Glycolysis Inhibition through miR-590-5p/HK2 Axis. [PDF]
Evid Based Complement Alternat Med, 2022 Colorectal cancer (CRC) is a frequent malignancy around the globe. Circular RNAs (circRNAs) are implicated in CRC development. Nevertheless, the regulatory mechanisms and biological functions regarding circRNAs in CRC progression are largely unclear.
Yang S, Zhao K, Yang X, Xing C.
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CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis. [PDF]
Oncogene, 2020 AbstractAccumulating evidences indicate that 3ʹUTR of the coding gene can act as crucial regulators in gastric cancer (GC). However, the detailed mechanisms and responsive targets are not well established. Here, we found thatacvr1bgene 3ʹUTR (acv3UTR) was elevated in GC tissue, the expression of which was significantly correlated with advanced pTNM ...
Liu K +9 more
europepmc +4 more sources
miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. [PDF]
Oncol Rep, 2018 The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR‑590‑5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription‑quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor ...
Mou K +6 more
europepmc +4 more sources
Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA. [PDF]
Virology, 2019 Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including coxsackievirus B cause infected cells to shed extracellular vesicles containing infectious virus. Recent reports have shown that vesicle-bound virus can infect more efficiently than free virus.
Germano JF +6 more
europepmc +3 more sources
Erratum: [Corrigendum] miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. [PDF]
Exp Ther MedGuo T, Wang J, Cheng G, Huang H.
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MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1. [PDF]
Sci Rep, 2016 AbstractOxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings.
Dai Y, Zhang Z, Cao Y, Mehta JL, Li J.
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Evaluation of BMP2/miRNA co-expression systems for potent therapeutic efficacy in bone-tissue regeneration [PDF]
European Cells & Materials, 2021 Reconstruction of bone defects and compensation of deficient repair mechanisms represent important goals within the field of regenerative medicine and require novel safe strategies for translation into the clinic.
TK Brenner +9 more
doaj +1 more source
Autoimmunity, 2021 Objective Asthma is a prevalent chronic inflammatory airway disease that is characterised by airway remodelling and airway hyperresponsiveness. Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) contribute to airway remodelling in
Wen-Lan Wang +5 more
doaj +1 more source
CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p. [PDF]
Cell Cycle, 2021 RNA pumilio RNA binding family member 1 (circPUM1) has been reported to play important roles in the tumorigenesis of several cancers. However, the underlying molecular role of circPUM1 in non-small cell lung cancer (NSCLC) progression remains unknown. The qRT-PCR and western blot were used to evaluate the expression of RNAs and proteins.
Li M, Wang Q, Zhang X, Yan N, Li X.
europepmc +3 more sources