Results 131 to 140 of about 53,504 (295)

Krüppel like factor 7 regulates mitochondrial dynamics balance in myocardial infarction

Communications Biology
Targeting the balance of mitochondrial fission and fusion can effectively alleviate the cardiac energy supply efficiency, to restore cardiac systolic dysfunction and reduce mortality.
Cao Wang, Fuxing Zhu, Lan Zhou, Situo Zhang, Ruiqi Wang, Hui Tian, Bosong Zhang, Jiahui Wu, Xiang Xu, Ruixian Jiang, Xiaolu Hou, Jian Liu, Weiming Tian   +12 more
doaj   +1 more source

Quantification of Mitochondrial Dynamics in Fission Yeast

Bio-Protocol, 2019
Mitochondria are double-membraned organelles responsible for several functions in the cell including energy production, calcium signaling, and cellular metabolism.
Leeba Chacko, Vaishnavi Ananthanarayanan
doaj   +1 more source

Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis. [PDF]

FASEB J, 2021
Adebayo M, Singh S, Singh AP, Dasgupta S.   +3 more
europepmc   +1 more source

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. [PDF]

, 2020
The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood.
Hu, Junjie, Li, Lei, Lou, Zhiyong, Nunnari, Jodi, Qi, Yuanbo, Rao, Zihe, Ricketson, Derek, Sarsam, Reta, Subramanian, Kelly, Wong, Melissa, Wu, Lijie, Yan, Liming, Yu, Caiting, Zhao, Jinghua   +13 more
core  

C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage

Frontiers in Pharmacology, 2019
Mitochondrial dysfunction is a predominant risk factor in ischemic heart disease, in which the imbalance of mitochondrial fusion and fission deteriorates mitochondrial function and might lead to cardiomyocyte death.
Jinchao Gao, Lidong Zhao, Jinfeng Wang, Lihang Zhang, Dandan Zhou, Jinlong Qu, Hao Wang, Ming Yin, Jiang Hong, Wenjuan Zhao   +9 more
doaj   +1 more source

Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. [PDF]

, 2019
Cells have evolved diverse protein-based machinery to reshape, cut, or fuse their membrane-delimited compartments. Dynamin superfamily proteins are principal components of this machinery and use their ability to hydrolyze GTP and to polymerize into ...
Frost, Adam, Kalia, Raghav
core  

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction. [PDF]

Nucleic Acid Ther, 2022
Garcia DA, Powers AF, Bell TA, Guo S, Aghajan M.   +4 more
europepmc   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

ZFP36L2 regulates myocardial ischemia/reperfusion injury and attenuates mitochondrial fusion and fission by LncRNA PVT1. [PDF]

Cell Death Dis, 2021
Wu F, Huang W, Tan Q, Guo Y, Cao Y, Shang J, Ping F, Wang W, Li Y.   +8 more
europepmc   +1 more source