A human mitofusin 2 mutation can cause mitophagic cardiomyopathy [PDF]
eLife, 2023 Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represented in
Antonietta Franco +12 more
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The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review [PDF]
Frontiers in Oral HealthPeriodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage.
Sudhir R. Varma +6 more
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Mitochonic acid 5 regulates mitofusin 2 to protect microglia [PDF]
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
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Mitofusin 2 displays fusion-independent roles in proteostasis surveillance [PDF]
Nature CommunicationsMitochondria are essential organelles and their functional state dictates cellular proteostasis. However, little is known about the molecular gatekeepers involved, especially in absence of external stress.
Mariana Joaquim +18 more
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Mitofusin-2: A New Mediator of Pathological Cell Proliferation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cell proliferation is an important cellular process for physiological tissue homeostasis and remodeling. The mechanisms of cell proliferation in response to pathological stresses are not fully understood.
Yanguo Xin +4 more
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The structure and function of mitofusin 2 and its role in cardiovascular disease through mediating mitochondria-associated endoplasmic reticulum membranes [PDF]
Frontiers in Cardiovascular MedicineCardiovascular disease (CVD) remains a leading cause of death globally, posing a major public health challenge. Due to the complexity of CVD's etiology, understanding its pathogenesis has been a significant challenge and research focus.
Yuhu Lv +9 more
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Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation [PDF]
Autophagy Reports, 2022 MFN2 (mitofusin 2) is a mitochondrial outer membrane protein that serves primarily as a mitochondrial fusion protein, which is its best known role but has additional functions in regulating cell biological processes.
Paola Zanfardino, Vittoria Petruzzella
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Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity [PDF]
Virulence, 2021 Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli.
In Soo Kim +2 more
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Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation [PDF]
Cells, 2022 Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2).
Jyoti Tanwar +12 more
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Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Frontiers in Cardiovascular Medicine, 2021 Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect
Mao Liu +5 more
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