Results 91 to 100 of about 10,801 (189)
Loss of Mfn1 but not Mfn2 enhances adipogenesis.
PLoS ONEObjectiveA biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth and/or ...
Jake P Mann +15 more
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, 2021 Programa de Doctorat en Biomedicina / Tesi realitzada a l'Institut de Recerca Biomèdica de Barcelona (IRBB)
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Effect of mitofusin 1 and mitofusin 2 deficiency on electrophysiology parameter following stimulated ischemia reperfusion [PDF]
, 2020 Background: Acute myocardial infarction (AMI) and the arrhythmias which often follow are among the leading causes of death and disability in Singapore and worldwide. As such novel treatments are required to prevent cardiac arrhythmias following AMI. In an AMI, acute myocardial ischemia and reperfusion can disturb the electrical conduction system of the
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The Journal of Physiology, EarlyView.Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana +2 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source
Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2
Pharmacological Research, 2018 The endoplasmic reticulum (ER) and the mitochondrial network are two highly interconnected cellular structures. By proteinaceous tethers, specialized membrane domains of the ER are tightly associated with the outer membrane of mitochondria, allowing the assembly of signaling platforms where different cell functions take place or are modulated, such as ...
Filadi, Riccardo +2 more
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Aging Cell, Volume 25, Issue 4, April 2026.FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 13, 3 March 2026.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
Mitofusin 2-Deficiency Suppresses Cell Proliferation through Disturbance of Autophagy
PLOS ONE, 2015 Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a mitochondrial fusion protein, has multiple functions in regulating cell biological processes. Defects of Mfn2 were found in diabetes, obesity, and neurodegenerative diseases.
Yanhong Ding +4 more
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