Results 151 to 160 of about 10,801 (189)
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Evaluation of the role of mitofusin‐1 and mitofusin‐2 in periodontal disease
Journal of Periodontology, 2023AbstractBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria‐endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation.
Ömer Alperen Kırmızıgül +5 more
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Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis
Kidney International, 2022Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.
Divya Bhatia +6 more
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Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Science Signaling, 2009A protein that mediates mitochondrial fusion also suppresses innate immune responses to viral infection.
Kai, Yasukawa +7 more
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Reproductive Sciences, 2022
Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Mitochondria are dynamic organelles that regulate their size, shape, and morphology through mechanisms called fusion and fission, to continually adapt themselves to their bioenergetic environment. These mechanisms play a critical role to maintain the mitochondrial function under metabolic and environmental stress.
Mauro Cozzolino, Yagmur Ergun, Emre Seli
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Mitofusin-2 in cancer: Friend or foe?
Archives of Biochemistry and Biophysics, 2022Cancer is a category of disorders characterized by excessive cell proliferation with the ability to infiltrate or disseminate to other organs of the body. Mitochondrial dysfunction, as one of the most prominent hallmarks of cancer cells, has been related to the onset and development of various cancers.
Pushpamala, Ramaiah +10 more
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Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Nature, 2008Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein mutated in the inherited motor ...
de Brito OM, SCORRANO, LUCA
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Relationship between mitofusin 2 and cancer
2019Mitochondria are dynamic organelles whose actions are fundamental for cell viability. Within the cell, the mitochondrial system is incessantly modified via the balance between fusion and fission processes. Among other proteins, mitofusin 2 is a central protagonist in all these mitochondrial events (fusion, trafficking, contacts with other organelles ...
A. Allegra +3 more
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Doxorubicin-induced cardiomyocyte apoptosis: Role of mitofusin 2
The International Journal of Biochemistry & Cell Biology, 2017Doxorubicin (DOX) is an anti-tumor agent that is widely used in clinical setting for cancer treatment. The application of the DOX, however, is limited by its cardiac toxicity which can induce heart failure through an undefined mechanism. Mitofusin 2 (Mfn2) is a mitochondrial GTPase fusion protein that is located on the outer membrane of mitochondria ...
Han, Tang +5 more
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Role of mitofusin 2 in cardiovascular oxidative injury
Journal of Molecular Medicine, 2010Mitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential ...
Ming, Zheng, Rui-Ping, Xiao
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