Results 31 to 40 of about 10,801 (189)
Mitofusin 2 Exerts a Protective Role in Ischemia Reperfusion Injury Through Increasing Autophagy
Cellular Physiology and Biochemistry, 2018 Background/Aims: Autophagy is essential for maintaining cellular homeostasis and the survival of terminally differentiated cells as neurons. In this study, we aim to investigate whether mitofusin 2, a mitochondrial fusion protein, mediates autophagy in ...
Cheng Peng +12 more
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Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled [PDF]
Signal Transduction and Targeted TherapyCamilla Aurora Franchino +2 more
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Regulating a uniter: control of mitofusin 2 expression [PDF]
Cardiovascular Research, 2012 This editorial refers to ‘The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells’ by E. Sorianello et al. , pp. 38–47, this issue. Sorianello et al. 1 provide important new information on the regulation on mitofusin (Mfn)2 expression.
Anne A, Knowlton, Le, Chen
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Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress [PDF]
Journal of Biological Chemistry, 2012 The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is unknown. We report here that induction of ER stress with either thapsigargin or tunicamycin in mouse embryonic fibroblasts leads to up-regulation of Mfn2 mRNA
Gladys A, Ngoh +2 more
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eLife, 2014 Mitochondrial fusion and fission affect the distribution and quality control of mitochondria. We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons.
Hector Sandoval +14 more
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Mitofusin 2 Builds a Bridge between ER and Mitochondria [PDF]
Cell, 2008 Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+
Merkwirth, C., Langer, T.
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MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites
Frontiers in Cell and Developmental Biology, 2022 Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress and the unfolded protein response (UPR ...
Benjamin Gottschalk +6 more
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Clinical and genetic characteristcs of hereditary motor and sensory neuropathy type IIA
Анналы клинической и экспериментальной неврологии, 2017 In this study, clinical manifestations of hereditary motor andsensory neuropathy type IIA (HMSN IIA, orCharcotMarieTooth disease type 2A) were analyzed in 22patients with the disease caused by different mutations of theMFN2 gene.
E. L. Dadali +2 more
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Frontiers in Endocrinology, 2023 Hormone-receptor signal transduction has been extensively studied in adrenal gland. Zona glomerulosa and fasciculata cells are responsible for glucocorticoid and mineralocorticoid synthesis by adrenocorticotropin (ACTH) and angiotensin II (Ang II ...
María Mercedes Mori Sequeiros Garcia +15 more
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The Journal of Qazvin University of Medical Sciences, 2020 Background Aerobic exercise with Blood Flow Restriction (BFR) plays an important role in skeletal muscle adaptation; however, the effects of this type of exercise on mitochondrial dynamics proteins are unclear.
Ali Aryashakib +2 more
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