Results 101 to 110 of about 3,785,189 (191)

Resistance to the “Last Resort” Antibiotic Colistin:A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes [PDF]

, 2020
MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the “last-resort” antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports
Visitsatthawong, Surawit, Mulholland, Adrian J, Oliveira, A Sofia F, Mulholland, Adrian, Lythell, Emily, Hinchliffe, Philip, Lee, Vannajan Sanghiran, Lang, Eric J M, Suardíaz, Reynier, Oliveira, Sofia, Lang, Eric, Fey, Natalie, Surawatanawong, Panida, Rungrotmongkol, Thanyada, Spencer, James, Hanpaibool, Chonnikan, Suardíaz Delrío, Reynier   +16 more
core   +1 more source

Prevalence and Genomic Characterization of mcr‐Positive Enterobacteriaceae in Retail Meat in Thailand Following the Colistin Ban

Microbiology and Immunology, Volume 70, Issue 9, Page 402-415, September 2026.
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf, Sharda Prasad Awasthi, Asmaa M. Elbastawesy, Noritoshi Hatanaka, Atsushi Hinenoya, Srinuan Somroop, Yukihiro Kaneko, Shinji Yamasaki   +7 more
wiley   +1 more source

Polymyxin Resistant Bacteria in Australian Poultry

Frontiers in Sustainable Food Systems, 2020
Resistance to last-resort antibiotics is significant public health issue. Antibiotic use in animal husbandry may be a driver of resistance that can subsequently be disseminated via the food chain.
David C. Bean, Sarah M. Wigmore, Muhd Haziq F. Abdul Momin, David W. Wareham, David W. Wareham   +4 more
doaj   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, Volume 73, Issue 6, Page 516-527, September 2026.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Old drug, new findings: colistin resistance and dependence of [PDF]

, 2017
Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii.
Ji-Young Lee, Kwan Soo Ko, Yujin Choi
core   +2 more sources

Detection of Plasmid-Mediated Resistance against Colistin in Multi-Drug-Resistant Gram-Negative Bacilli Isolated from a Tertiary Hospital

, 2023
The aim of this study was to determine the prevalence of plasmid-mediated colistin resistance mcr-1 to mcr-5 genes among colistin and multi-drug-resistant Gram-negative bacilli strains isolated from patients in a tertiary hospital in Toluca, Mexico.
Laura Guadarrama-Monroy, José David Santiago-Luna, Reinaldo Pacheco-Vásquez, Humberto Navarrete-Salazar, Isabel Baltazar-Jiménez, Mario Galindo-Méndez, Devanhí Quintas-de la Paz   +6 more
core   +1 more source

NMCR-6, a novel nonmobile colistin resistance gene in Vibrio bacteria: full characterization and global perspective

Decoding Infection and Transmission
Objective: Amid rising bacterial resistance, polymyxins are a critical last resort against multidrug-resistant Gram-negative infections. Understanding and predicting the emergence of novel, nonmobile colistin resistance (NMCR) genes are essential to ...
Xinkun Zhu, Junyang Ma, Renge Hu, Qing Yang, Lei Yang, Shu Li, Yuanhuan Kang, Zhenlin Liang, Hany M. Elsheikha, Wei Cong   +9 more
doaj   +1 more source

Molecular mechanisms related to colistin resistance in Enterobacteriaceae

, 2019
Zahra Aghapour,1,2 Pourya Gholizadeh,3 Khudaverdi Ganbarov,4 Abed Zahedi Bialvaei,5 Suhad Saad Mahmood,6 Asghar Tanomand,7 Mehdi Yousefi,8 Mohammad Asgharzadeh,9 Bahman Yousefi,9 Hossein Samadi Kafil11Drug Applied Research Center, Tabriz University of ...
Ganbarov K, Aghapour Z, Yousefi M, Yousefi B, Kafil HS, Asgharzadeh M, Gholizadeh P, Bialvaei AZ, Mahmood SS, Tanomand A   +9 more
core  

Colistin: from the shadows to a One Health approach for addressing antimicrobial resistance

, 2023
International audienceAntimicrobial resistance (AMR) poses a serious threat to human, animal and environmental health worldwide. Colistin has regained importance as a last-resort treatment against multi-drug-resistant Gram-negative bacteria.
Madec, Jean-Yves, Laxminarayan, Ramanan, Rhouma, Mohamed   +2 more
core   +1 more source

First report of the plasmid-borne colistin resistance gene (mcr-1) in Proteus mirabilis isolated from a toddler in non-clinical settings

IDCases, 2019
We report the detection of a plasmid-borne mobile colistin-resistance-gene, mcr-1, in Proteus mirabilis, a known community and hospital pathogen, that was isolated from a toddler (2 years old) in the community in Lebanon.
Zaynab Hmede, Issmat I. Kassem
doaj   +1 more source