Results 81 to 90 of about 3,600,199 (198)

Acinetobacter baumannii under Acidic Conditions Induces Colistin Resistance through PmrAB Activation and Lipid A Modification

, 2023
Colistin is a last-resort antimicrobial agent for treating carbapenem-resistant Acinetobacter baumannii infections. The activation of PmrAB by several environmental signals induces colistin resistance in Gram-negative bacteria.
Minsang Shin, Je-Chul Lee, Seong-Yong Park, Seong-Yeop Kim, Seo-Yeon Ko, Nayeong Kim   +5 more
core   +1 more source

Antibiotic Resistance and Biofilm‐Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Key finding: Antimicrobial resistance was common across all groups and associated with biofilm‐forming capacity, an association that remains observational and species‐confounded. ABSTRACT This study aimed to analyse antimicrobial resistance (AMR) in bacterial isolates from subgingival biofilms of patients with periodontitis and supragingival biofilms ...
Nils Werner, Marie Schöffel, Annette Wittmer, Klaus Pelz, Kirstin Vach, Cornelia Frese, Christiane von Ohle, Diana Wolff, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Association of Carbapenem and Colistin Resistance in Pathogenic Gram Negative Bacteria

, 2019
Diseases caused by multidrug-resistant (MDR) bacteria continue to challenge physicians and endanger their patients’ lives. Polymyxins, including colistin, are the last resort antibiotics to treat serious infections caused by carbapenem-resistant ...
Walid Bakeer, Sanaa Fadel, Magdi Amin, Reham Osama   +3 more
core   +1 more source

Development of novel antibodies for detection of mobile colistin-resistant bacteria contaminated in meats

Scientific Reports, 2018
AbstractThe recent discovery and rapid spread of mobile colistin-resistant gene, mcr-1, among bacteria isolated from a broad range of sources is undermining our ability to treat bacterial infections and threatening human health and safety. To prevent further transfer of colistin resistance, practical and reliable methods for mcr-1-containing bacteria ...
Xiaohua He, Daniela Mavrici, Stephanie Patfield, Fernando M. Rubio   +3 more
openaire   +2 more sources

In Vitro Study of IS Apl1 -Mediated Mobilization of the Colistin Resistance Gene mcr-1 [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The mcr-1 gene is associated with insertion sequence IS Apl1 (IS 30 family).
Poirel L, Kieffer N, Nordmann P
openaire   +5 more sources

Comparative Genomic Analysis of Multidrug‐Resistant Escherichia coli Across Poultry–Human–Environmental Interfaces

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Whole‐genome sequencing analysis of Escherichia coli isolates from broiler, layer and sonali chickens in Bangladesh shown extensive antimicrobial resistance, diverse virulence factors, plasmid‐mediated resistance, and a highly open pangenome. Comparative genomic analyses demonstrated close genetic relationships with global strains, highlighting the One
Md. Rokibul Hasan Shanto, A. S. M. Ashab Uddin, Md. Shakil Mahmud Supto, Nabil Jahan Mahim, Md. Matiar Rahman Howlader, Syed Sayeem Uddin Ahmed, Md Bashir Uddin   +6 more
wiley   +1 more source

Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Comparison of proteomes from three series of sequential Pseudomonas aeruginosa isolates from people with cystic fibrosis identified eleven proteins with increased abundance in at least one late isolate per patient. Three proteins were increased in all five late isolates, and the probability of this occurring by chance is 5.06 × 10−53, indicating strong
Joanna Drabinska, Lucia O'Connor, Caoilin McClean, Siobhán McClean   +3 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Intracellular Transposition of Mobile Genetic Elements Associated with the Colistin Resistance Gene mcr-1

Microbiology Spectrum, 2023
By analyzing the intracellular transfer of clinically relevant transposons, we can understand the dissemination and evolution of drug resistance conferring mobile genetic elements (MGEs) once a plasmid enters a cell following conjugation. This knowledge will help further our understanding of how these important genes move through bacterial
Richard N. Goodman, Supathep Tansirichaiya, Michael S. M. Brouwer, Adam P. Roberts   +3 more
openaire   +4 more sources

Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug‐Resistant Bacteria: Preliminary Antibiotic–Interaction Screening and Exploratory Molecular Docking

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The methanolic extract of Cinnamomum verum exhibited antibacterial and antibiofilm activities, enhanced the efficacy of conventional antibiotics against multidrug‐resistant bacteria, and showed favorable interactions with key bacterial targets in molecular docking analyses, supporting its potential as a natural antimicrobial adjuvant for combating ...
Hayet Edziri, Sarra Elmsehli, Assia kenich, Mabrouk Horchani, Hanen Najjaa, Naima Najah, Hasan Aljohi, Mohammad Nasser Alkhrayef, Roberta Ascrizzi, Guido Flamini, Ibrahim O. Alanazi, Mozaniel Santana de Oliveira   +11 more
wiley   +1 more source