Results 61 to 70 of about 3,600,199 (198)

Characteristics and genomic epidemiology of colistin-resistant Enterobacterales from farmers, swine, and hospitalized patients in Thailand, 2014–2017

BMC Infectious Diseases, 2023
Background Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics.
Adhiratha Boonyasiri, Lauren M. Brinkac, Elita Jauneikaite, Richard C. White, Chris Greco, Chakkraphong Seenama, Teerawit Tangkoskul, Kevin Nguyen, Derrick E. Fouts, Visanu Thamlikitkul   +9 more
doaj   +1 more source

Prevalence of colistin-resistant Escherichia coli in foods and food-producing animals through the food chain: A worldwide systematic review and meta-analysis

Heliyon
The purpose of this systematic review and meta-analysis was to summarize the available scientific evidence on the prevalence of colistin-resistant Escherichia coli strains isolated from foods and food-producing animals, the mobile colistin-resistant ...
Florencia Aylen Lencina, Matías Bertona, María Angeles Stegmayer, Carolina Raquel Olivero, Laureano Sebastián Frizzo, Jorge Alberto Zimmermann, Marcelo Lisandro Signorini, Lorena Paola Soto, María Virginia Zbrun   +8 more
doaj   +1 more source

The MCR-3 inside linker appears as a facilitator of colistin resistance

Cell Reports, 2021
Summary: An evolving family of mobile colistin resistance (MCR) enzymes is threatening public health. However, the molecular mechanism by which the MCR enzyme as a rare member of lipid A-phosphoethanolamine (PEA) transferases gains the ability to confer ...
Yongchang Xu, Haiyi Chen, Huimin Zhang, Saif Ullah, Tingjun Hou, Youjun Feng   +5 more
doaj   +1 more source

Environmental mediation of colistin resistance in the African context. A systematic scoping review

Journal of Global Antimicrobial Resistance
Objectives: The prevalence of antimicrobial resistance (AMR) among Gram-negative bacteria is a major global health concern. Resistance to last-resort antibiotics like colistin is particularly alarming.
Emmanuel Udochukwu Osisiogu, Fareeda Ceeta Mahmoud, Fahad Bin Waqas, Bhavana Singh, Patrick K. Feglo, Kwabena Obeng Duedu   +5 more
doaj   +1 more source

Outer membrane permeability of mcr-positive bacteria reveals potent synergy of colistin and macromolecular antibiotics against colistin-resistant Acinetobacter baumannii

Frontiers in Microbiology
Colistin (CT) is the last-resort of antibiotic against multidrug-resistance (MDR) Acinetobacter baumannii (A. baumannii) infection. However, colistin resistance is increasingly reported in A.
Meisong Li, Furong Ma, Hui Zhao, Dianrong Zhou, Dianrong Zhou, Dianrong Zhou, Lujie Liang, Lujie Liang, Lujie Liang, Runling Lv, Jiachen Li, Jiachen Li, Jiachen Li, Yaxuan Wang, Yaxuan Wang, Yaxuan Wang, Lin Xu, Lin Xu, Lin Xu, Chenfei Liu, Guo-Bao Tian, Guo-Bao Tian, Guo-Bao Tian, Siyuan Feng, Siyuan Feng, Siyuan Feng, Yong Xia   +26 more
doaj   +1 more source

Definition of a Family of Nonmobile Colistin Resistance (NMCR‐1) Determinants Suggests Aquatic Reservoirs for MCR‐4

Advanced Science, 2019
Polymyxins, a family of cationic antimicrobial peptides, are recognized as a last‐resort clinical option used in the treatment of lethal infections with carbapenem‐resistant pathogens.
Huimin Zhang, Wenhui Wei, Man Huang, Zeeshan Umar, Youjun Feng   +4 more
doaj   +1 more source

Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges

, 2020
Colistin has been extensively used since the middle of the last century in animals, particularly in swine, for the control of enteric infections. Colistin is presently considered the last line of defense against human infections caused by multidrug ...
Ferdinando F. Andrade, Daniela Silva, Acácio Rodrigues, Cidália Pina-Vaz   +3 more
core   +1 more source

Surveillance and Genomic Characterisation of Colistin-Resistant Gram-Negative Bacteria in the Drains of High-Risk Hospital Units

Journal of Global Antimicrobial Resistance
: Objective: The health care water environment, including sinks and drainage systems, can be a long-term reservoir of nosocomial pathogens. In this study, we aimed to investigate the presence of colistin-resistant Gram-negative (ColR-GN) bacteria in ...
Giuseppe Fleres, Alessia Mirabile, Mariëtte Lokate, John W.A. Rossen, Natacha Couto, Alexander W. Friedrich, Silvia García-Cobos   +6 more
doaj   +1 more source

Colistin Resistance Mechanisms in Human and Veterinary Klebsiella pneumoniae Isolates

, 2022
Colistin (polymyxin E) is increasingly used as a last-resort antibiotic for the treatment of severe infections with multidrug-resistant Gram-negative bacteria.
Lisa Sedlaczek, Paul G. Higgins, Stephan Göttig, Higgins, Paul G., Manuela Tietgen, Christa Ewers, Kaspar, Heike, Ewers, Christa, Göttig, Stephan, Sedlaczek, Lisa, Heike Kaspar, Tietgen, Manuela   +11 more
core   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source