Results 91 to 100 of about 487,050 (179)

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate [PDF]

, 2012
The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530
Wenyan Wang (171659), Bukh, J., Felix A Rey, Yong Wang (12837), Wang, Yong, Zhen-yong Keck (171653), Jannick Prentoe (162323), Lemon, S.M., Jannick Prentoe, Jens Bukh (162343), Steven K. H. Foung (171667), Lemon, Stanley M., Prentoe Jannick, Foung Steven K. H., Thomas Carlsen (171662), Carlsen, Thomas, Rey, F.A., Patel, Arvind H., Li, A.Y., Patel, A.H., Steven K H Foung, Carlsen Thomas, Bukh, Jens, Xia, J., Zhen-yong Keck, Li, Angela Ying-Jian, Wenyan Wang, Keck, Zhen-yong, Thomas Krey, Wang, Y., Rey Felix A., Yong Wang, Foung, S.K.H., Arvind H. Patel (33806), Patel, Arvind H, Lemon, Stanley M, Krey Thomas, Keck Zhen-yong, Wang Wenyan, Rey, Felix A., Prentoe, Jannick, Arvind H Patel, Bukh Jens, Stanley M Lemon, Krey, T., Angela Ying-Jian Li, Felix A. Rey (171664), Foung, Steven K H, Thomas Krey (171661), Keck, Z., Xia Jinming, Krey, Thomas, Jinming Xia (171656), Stanley M. Lemon (30543), Wang, Wenyan, Lemon Stanley M., Patel Arvind H., Rey, Felix A, Li Angela Ying-Jian, Jinming Xia, Xia, Jinming, Foung, Steven K. H., Thomas Carlsen, Wang, W., Prentoe, J., Jens Bukh, Angela Ying-Jian Li (171663), Carlsen, T., Wang Yong   +68 more
core   +1 more source

Structure-guided design of antibody CDRs to reduce their reactivity to treatment-emergent anti-drug antibodies

mAbs
Immunogenicity prediction is widely used in the developability assessment of antibodies, and many marketed and clinical-stage therapeutics have a predicted T-cell epitope in the second complementary-determining region of their light chain (CDR2L).
Maria U. Johansson, Anne Kerschenmeyer, Alessandra Carella, Simon Carnal, Yannik Schmidt, Alessandra de Felice, Dana Mahler, Marc Thomas, Fabio Mario Spiga, Julia Tietz, Christopher Weinert, Christian Hess, David Urech, Stefan Warmuth   +13 more
doaj   +1 more source

mRNA-mediated delivery of anti-HIV-1 multispecific antibodies as a passive immunisation strategy

A research report submitted in fulfillment of the requirements for the Master of Science in Medicine, in the Faculty of Health Sciences, School of Pathology, University of the Witwatersrand, Johannesburg, 2024HIV-1 broadly neutralising antibodies (bNAbs)
O’Connor, Caitlyn
core  

Antibodies and cryptographic hash functions: quantifying the specificity paradox

Frontiers in Immunology
The specificity of the immune response is critical to its biological function, yet the generality of immune recognition implies that antibody binding is multispecific or degenerate.
Robert J. Petrella, Robert J. Petrella
doaj   +1 more source

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies. [PDF]

Biol Chem, 2022
Dickopf S, Buldun C, Vasic V, Georges G, Hage C, Mayer K, Forster M, Wessels U, Stubenrauch KG, Benz J, Ehler A, Lauer ME, Ringler P, Kobold S, Endres S, Klein C, Brinkmann U.   +16 more
europepmc   +1 more source

Characterisation of HLA-specific antibodies [PDF]

A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the ...
Lowe, David Philip
core  

Development of Bispecific Antibody Targeting Human IL-17A and IL-6

Antibodies
Background/Objectives: Antibodies are a rapidly expanding field in drug discovery, but their monospecificity limits therapeutic applications, particularly in complex inflammatory diseases.
Beata Pamuła, Martyna Banach, Marta Mikońska, Karolina Korytkowska, Krzysztof Lacek, Oliwia Śniadała, Małgorzata Marczak, Krzysztof Flis, Aleksandra Sowińska, Damian Kołakowski, Jerzy Pieczykolan, Beata Zygmunt, Maciej Wieczorek, Olga Abramczyk   +13 more
doaj   +1 more source

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Frontiers in Chemical Biology
ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane ...
Rick Janssens, Rick Janssens, Rien van Haperen, Rien van Haperen, Michael van der Reijden, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Frank Grosveld, Dubravka Drabek, Dubravka Drabek   +11 more
doaj   +1 more source

Updated transient gene expression protocol in Expi293F cells using PEI

Frontiers in Bioengineering and Biotechnology
Transient gene expression (TGE) is commonly used for the rapid production of protein-based therapeutics, including antibodies that require post-translational modifications.
Gustaf Hederoth, Andrés de la Rosa, Ana Godec, Ximena Aguilar, Antonino Napoleone, Alex Petrovic, Nicole G. Metzendorf, Greta Hultqvist   +7 more
doaj   +1 more source