Results 81 to 90 of about 2,301 (144)

Updated transient gene expression protocol in Expi293F cells using PEI

Frontiers in Bioengineering and Biotechnology
Transient gene expression (TGE) is commonly used for the rapid production of protein-based therapeutics, including antibodies that require post-translational modifications.
Gustaf Hederoth, Andrés de la Rosa, Ana Godec, Ximena Aguilar, Antonino Napoleone, Alex Petrovic, Nicole G. Metzendorf, Greta Hultqvist   +7 more
doaj   +1 more source

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Frontiers in Chemical Biology
ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane ...
Rick Janssens, Rick Janssens, Rien van Haperen, Rien van Haperen, Michael van der Reijden, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Frank Grosveld, Dubravka Drabek, Dubravka Drabek   +11 more
doaj   +1 more source

Antibodies to watch in 2025

mAbs
The commercial development of antibody therapeutics is a global enterprise involving thousands of biopharmaceutical firms and supporting service organizations. To date, their combined efforts have resulted in over 200 marketed antibody therapeutics and a
Silvia Crescioli, Hélène Kaplon, Lin Wang, Jyothsna Visweswaraiah, Vaishali Kapoor, Janice M. Reichert   +5 more
doaj   +1 more source

Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R

, 2023
Nguyen HT, Gurvich N, Gillrie MR, Offeddu G, Humayun M, Kan EL, Wan Z, Coughlin MF, Zhang C, Vu V, Ling Lee SW, Tan S, Barbie D, Hsu J, Kamm RD.   +14 more
europepmc   +1 more source

The intriguing options of multispecific antibody formats for treatment of cancer.

Cancer genomics & proteomics, 2013
The advent of various technologies for the generation of bi- and multispecific recombinant antibody-based molecules brought with it a multitude of formats for selecting target combinations. Some of the format options are outlined from a technical point of view. We focus on the achievements and prospects of the underlying technologies for generating bi-
Ulrich H, Weidle, Georg, Tiefenthaler, Elisabeth H, Weiss, Guy, Georges, Ulrich, Brinkmann   +4 more
openaire   +1 more source

Engineered Technologies and Bioanalysis of multispecific Antibody Formats

Journal of Applied Bioanalysis, 2020
Marta Amaral, Soraya Hölper, Christian Lange, Jennifer Jung, Hanno Sjuts, Sandra Weil, Melanie Fischer, Katarina Radoevic, Ercole Rao   +8 more
openaire   +1 more source

End-To-End Automated Intact Protein Mass Spectrometry for High-Throughput Screening and Characterization of Bispecific and Multispecific Antibodies. [PDF]

Anal Chem
Niu B, Lee B, Chen W, Alberto C, Betancourt Moreira K, Compton P, Homan K, Pinckney J, Zhu Y, Vendel M, Wetterhorn K, Walrond S, Santha E, Horowitz A, Zaubi N, Johnson J.   +15 more
europepmc   +1 more source

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains. [PDF]

Sci Rep, 2016
Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Cuesta AM, Blanco-Toribio A, Harwood SL, Villate M, Merino N, Bonet J, Navarro R, Muñoz-Briones C, Sørensen KM, Mølgaard K, Oliva B, Sanz L, Blanco FJ, Alvarez-Vallina L.   +16 more
europepmc   +1 more source

Nomenclature of therapies in inflammatory bowel disease: A journey through time and terminology. [PDF]

Inflamm Bowel Dis
Colwill M, Patel K, Sebastian S, Din S, Honap S.   +4 more
europepmc   +1 more source

B cells enable autoreactive T cells to avoid suppression. [PDF]

Proc Natl Acad Sci U S A
Funsten M, de Pooter R, Varanasi V, Burrows M, Block K, Kuznetsov A, Serreze D, Huang H, Chervonsky A.   +8 more
europepmc   +1 more source