Results 61 to 70 of about 487,050 (179)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 614-638, September 2026.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Multispecific antibodies targeting CD38 show potent tumor-specific cytotoxicity.

, 2018
57 Background: Multivalent antibodies targeting either CD38 alone or CD38 in conjunction with PD-L1 may yield therapeutics with superior biological activities and provide benefit for treating malignancies expressing low levels of CD38 (MCL, NHL, T cell
Shelley Force Aldred, Ben Buelow, Kevin Dang, Andrew Boudreau, Wim Van Schooten, Brett Jorgensen, Heather Ogana, Starlynn Clarke, Katherine Harris, Ute Schellenberger, Harshad Ugamraj, Laura Davison, Suhasini Iyer, Duy Pham, Omid Vafa, Udaya Rangaswamy, Payal Pratap, Nathan Trinklein   +17 more
core   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

Neuropathophysiological potential of Guillain-Barré syndrome anti-ganglioside-complex antibodies at mouse motor nerve terminals [PDF]

, 2011
Objectives:  Anti-ganglioside antibodies are present in approximately half of Guillain–Barré syndrome (GBS) patients. Recently, it has been shown that a considerable proportion of these patients has serum antibodies against antigenic epitopes formed by a
Susumu Kusunoki, Tio-Gillen, Anne P., Plomp, J.J., Kusunoki, Susumu, Tio-Gillen, A.P., Willison, H.J., Broos, Ludo A.M., Ueda, M., Mark L. Kuijf, Ludo A. M. Broos, Kuijf, Mark L., Jacobs, B.C., Greenshields, Kay N., Jacobs, Bart C., Zitman, F.M.P., Hugh J. Willison, Anne P. Tio-Gillen, Masami Ueda, Kuijf, M.L., Jaap J. Plomp, Kusunoki, S., Greenshields, K.N., Plomp, Jaap J., Femke M. P. Zitman, Broos, L.A.M., Kay N. Greenshields, Ken-ichi Kaida, Willison, Hugh J., Bart C. Jacobs, Kaida, Ken Ichi, Kaida, K.I., Ueda, Masami, Zitman, Femke M.P.   +32 more
core   +1 more source

Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity

Emerging Microbes and Infections, 2020
Coronaviruses cause severe human viral diseases including SARS, MERS and COVID-19. Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics.
Jianbo Dong, Betty Huang, Zhejun Jia, Bo Wang, Sachith Gallolu Kankanamalage, Allison Titong, Yue Liu   +6 more
doaj   +1 more source

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
Eisenmenger, Wolfgang, Schmidberger, F., Funke, I., Kurrle, R., Martin, B., Stavrou, D., Bise, K., Stocker, U., Keiditsch, E.   +8 more
core   +1 more source

Antibody Multispecificity Mediated by Conformational Diversity

Science, 2003
A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre–steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing ...
James L. C., Roversi P., Tawfik D. S.
openaire   +4 more sources

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Bispecific and trispecific antibodies in atopic dermatitis: a review of the emerging clinical pipeline

Frontiers in Drug Discovery
Biologic therapies have reshaped treatment of atopic dermatitis, yet most available agents target only one cytokine or receptor and many patients still do not reach minimal disease activity.
Gili Amid-Toby, Omar Alani, Christopher G. Bunick   +2 more
doaj   +1 more source