Results 61 to 70 of about 2,301 (144)
Antibody‐Empowered Nanomedicine for Precise Biomedical Applications
Advanced Science, Volume 13, Issue 10, 18 February 2026.This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen +7 more
wiley +1 more source
Frontiers in Drug DiscoveryBiologic therapies have reshaped treatment of atopic dermatitis, yet most available agents target only one cytokine or receptor and many patients still do not reach minimal disease activity.
Gili Amid-Toby +2 more
doaj +1 more source
New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness
Frontiers in Immunology, 2017 Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently ...
Isabel Corraliza-Gorjón +4 more
doaj +1 more source
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
[Multispecific monoclonal antibodies].
Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1992 Immunization of BALB/c mice with Rickettsia prowazekii antigens, Bordetella pertussis toxin and Legionella pneumophila cytolysin induces the synthesis of IgM autoantibodies of different specificity. Among monoclonal antibodies, multispecific antibodies with a wide reactivity spectrum have been found to make up high percentage (30-80%).
E I, Drobyshevskaia +3 more
openaire +1 more source
A Tutorial on the Development of a Physiologically Inspired PKRO Model for Monoclonal Antibodies
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Modeling and simulations are indispensable tools to describe pharmacokinetics (PK) and pharmacodynamics to support monoclonal antibody (mAb) development. The linear PK of mAbs is commonly described by a 2‐compartment PK model, while the nonlinear PK often observed at low doses is described by target mediated drug disposition (TMDD) models ...
Georgi I. Kapitanov +5 more
wiley +1 more source
AntibodiesTherapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific antibodies are pivotal in therapeutic protein development and have transformed disease treatments across various therapeutic areas.
Ben Niu +4 more
doaj +1 more source
Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics
Frontiers in Immunology, 2017 Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-
Peter Bannas +2 more
doaj +1 more source
AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
mAbs, 2020 As biologics have become a mainstay in the development of novel therapies, protein engineering tools to expand on their structural advantages, namely specificity, affinity, and valency are of interest.
Mario Sanches +13 more
doaj +1 more source