Results 71 to 80 of about 487,050 (179)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness

Frontiers in Immunology, 2017
Antibodies have proven their high value in antitumor therapy over the last two decades. They are currently being used as the first-choice to treat some of the most frequent metastatic cancers, like HER2+ breast cancers or colorectal cancers, currently ...
Isabel Corraliza-Gorjón, Beatriz Somovilla-Crespo, Silvia Santamaria, Jose A. Garcia-Sanz, Leonor Kremer   +4 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

The Accurate Prediction of Antibody Deamidations by Combining High-Throughput Automated Peptide Mapping and Protein Language Model-Based Deep Learning

Antibodies
Therapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific antibodies are pivotal in therapeutic protein development and have transformed disease treatments across various therapeutic areas.
Ben Niu, Benjamin Lee, Lili Wang, Wen Chen, Jeffrey Johnson   +4 more
doaj   +1 more source

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta [PDF]

, 2002
Organic anion-transporting polypeptides (OATPs) are a family of multispecific carriers that mediate the sodium-independent transport of steroid hormone and conjugates, drugs, and numerous anionic endogenous substrates.
Stallmach, T., Hagenbuch, B., Ugele, B., Meier, P. J., St-Pierre, M. V.   +4 more
core   +1 more source

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

Frontiers in Immunology, 2017
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-
Peter Bannas, Julia Hambach, Friedrich Koch-Nolte   +2 more
doaj   +1 more source

Acknowledgement to Reviewers of Antibodies in 2014

, 2015
The editors of Antibodies would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2014:[...
Antibodies Editorial Office
core   +1 more source

Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

mAbs
Immunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication.
Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp   +9 more
doaj   +1 more source

Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer

Antibodies, 2019
In the last decade, cancer immunotherapies have produced impressive therapeutic results. However, the potency of immunotherapy is tightly linked to immune cell infiltration within the tumor and varies from patient to patient.
Timothée Chanier, Patrick Chames
doaj   +1 more source

Acknowledgement to Reviewers of Antibodies in 2015

, 2016
The editors of Antibodies would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015.
Antibodies Editorial Office
core   +1 more source