Results 71 to 80 of about 2,313 (149)

Development of Bispecific Antibody Targeting Human IL-17A and IL-6

Antibodies
Background/Objectives: Antibodies are a rapidly expanding field in drug discovery, but their monospecificity limits therapeutic applications, particularly in complex inflammatory diseases.
Beata Pamuła, Martyna Banach, Marta Mikońska, Karolina Korytkowska, Krzysztof Lacek, Oliwia Śniadała, Małgorzata Marczak, Krzysztof Flis, Aleksandra Sowińska, Damian Kołakowski, Jerzy Pieczykolan, Beata Zygmunt, Maciej Wieczorek, Olga Abramczyk   +13 more
doaj   +1 more source

Updated transient gene expression protocol in Expi293F cells using PEI

Frontiers in Bioengineering and Biotechnology
Transient gene expression (TGE) is commonly used for the rapid production of protein-based therapeutics, including antibodies that require post-translational modifications.
Gustaf Hederoth, Andrés de la Rosa, Ana Godec, Ximena Aguilar, Antonino Napoleone, Alex Petrovic, Nicole G. Metzendorf, Greta Hultqvist   +7 more
doaj   +1 more source

Toward Drug-Like Multispecific Antibodies by Design. [PDF]

Int J Mol Sci, 2020
Sawant MS, Streu CN, Wu L, Tessier PM.
europepmc   +1 more source

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Frontiers in Chemical Biology
ObjectiveMesothelin (MSLN) is an attractive target for anticancer therapeutics and bioimaging reagents that utilize antibodies. This study was aimed at developing a novel human anti-MSLN single-domain antibody that exclusively binds to the membrane ...
Rick Janssens, Rick Janssens, Rien van Haperen, Rien van Haperen, Michael van der Reijden, Michael van der Reijden, Alex Maas, Jingsong Wang, Frank Grosveld, Frank Grosveld, Dubravka Drabek, Dubravka Drabek   +11 more
doaj   +1 more source

[Multispecific monoclonal antibodies].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1992
Immunization of BALB/c mice with Rickettsia prowazekii antigens, Bordetella pertussis toxin and Legionella pneumophila cytolysin induces the synthesis of IgM autoantibodies of different specificity. Among monoclonal antibodies, multispecific antibodies with a wide reactivity spectrum have been found to make up high percentage (30-80%).
E I, Drobyshevskaia, S V, Spitsyn, Iu A, Nedialkov, V G, Nesterenko   +3 more
openaire   +1 more source

Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R

, 2023
Nguyen HT, Gurvich N, Gillrie MR, Offeddu G, Humayun M, Kan EL, Wan Z, Coughlin MF, Zhang C, Vu V, Ling Lee SW, Tan S, Barbie D, Hsu J, Kamm RD.   +14 more
europepmc   +1 more source

Evolution of bispecific and multispecific antibodies in cancer therapy. [PDF]

Lancet Reg Health Eur
Fontana E, Grochot R, Kotecki N, Doger B, Nannini S, de Miguel M.   +5 more
europepmc   +1 more source

The use of CrossMAb technology for the generation of bi- and multispecific antibodies. [PDF]

MAbs, 2016
Klein C, Schaefer W, Regula JT.
europepmc   +1 more source

End-To-End Automated Intact Protein Mass Spectrometry for High-Throughput Screening and Characterization of Bispecific and Multispecific Antibodies. [PDF]

Anal Chem
Niu B, Lee B, Chen W, Alberto C, Betancourt Moreira K, Compton P, Homan K, Pinckney J, Zhu Y, Vendel M, Wetterhorn K, Walrond S, Santha E, Horowitz A, Zaubi N, Johnson J.   +15 more
europepmc   +1 more source

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains. [PDF]

Sci Rep, 2016
Alvarez-Cienfuegos A, Nuñez-Prado N, Compte M, Cuesta AM, Blanco-Toribio A, Harwood SL, Villate M, Merino N, Bonet J, Navarro R, Muñoz-Briones C, Sørensen KM, Mølgaard K, Oliva B, Sanz L, Blanco FJ, Alvarez-Vallina L.   +16 more
europepmc   +1 more source