RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis [PDF]
Nature Communications, 2018 Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the ...
Uwe Richter +9 more
doaj +13 more sources
RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma. [PDF]
Front Immunol, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Mao M, Chu Q, Lou Y, Lv P, Wang LJ.
europepmc +3 more sources
Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives [PDF]
, 2023 Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1 ...
Belluti, Silvia +6 more
core +4 more sources
The N1‐methyladenosine methyltransferase TRMT61A promotes bladder cancer progression and is targetable by small molecule compounds [PDF]
Clinical and Translational MedicineJianjian Yin +13 more
doaj +2 more sources
MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
Cancer Medicine, 2023 Background Distant metastasis is the main cause of mortality in colorectal cancer (CRC) patients. N1‐methyladenosine (m1A) is a type of epitranscriptome modification.
Meng Xue +6 more
doaj +1 more source
Sequencing methods and functional decoding of mRNA modifications
Fundamental Research, 2023 More than 160 types of post-transcriptional RNA modifications have been reported; there is substantial variation in modification type, abundance, site, and function across species, tissues, and RNA type.
Kai Li, Jinying Peng, Chengqi Yi
doaj +1 more source
Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
doaj +1 more source
Research progress on mRNA methylation and diseases [PDF]
Jichu yixue yu linchuang, 2021 mRNA methylation modification, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA.
LI Ran, HAO Yan-lei
doaj
Nature Communications, 2022 RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su +6 more
doaj +1 more source
Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
Frontiers in Genetics, 2022 As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate.
Hui-Ming Chen +9 more
doaj +1 more source