Results 21 to 30 of about 4,176 (133)

Towards a 'druggable' epitranscriptome: Compounds that target RNA modifications in cancer [PDF]

, 2021
Epitranscriptomics is an exciting emerging area that studies biochemical modifications of RNA. The field is boosted by the technical efforts of the last decade to characterize and quantify RNA modifications which have led to a map of post-transcripcional
Berdasco, María, Esteller, Manel
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Recent Advances in Identification of RNA Modifications

Non-Coding RNA, 2016
RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions.
Wei Chen, Hao Lin
doaj   +1 more source

MePMe-seq: antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing

Nature Communications, 2023
Internal modifications of mRNA have emerged as widespread and versatile regulatory mechanism to control gene expression at the post-transcriptional level.
Katja Hartstock, Nadine A. Kueck, Petr Spacek, Anna Ovcharenko, Sabine Hüwel, Nicolas V. Cornelissen, Amarnath Bollu, Christoph Dieterich, Andrea Rentmeister   +8 more
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Research Progress of RNA Methylation Modification in Colorectal Cancer

Frontiers in Pharmacology, 2022
Accumulating evidence indicates that RNA methylation, as the most common modification of mRNA, is of great significance in tumor progression and metastasis.
Weizheng Liang, Hongyang Yi, Chenyu Mao, Qingxue Meng, Xueliang Wu, Shanliang Li, Jun Xue   +6 more
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Improved ontology for eukaryotic single-exon coding sequences in biological databases [PDF]

, 2018
Indexación: Scopus.Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term 'single-exon
Clausen, P., González, C., Holmes, D.S., Jorquera, R., Petersen, B.   +4 more
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The protective role of m1A during stress-induced granulation [PDF]

, 2020
Post-transcriptional methylation of N6- and N1-adenine can effect transcriptome turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m6A) during heat shock has been uncovered, including the enhancement of the phase ...
Alriquet, Marion, Calloni, Giulia, Martínez-Limón, Adrían, Ponti, Riccardo Delli, Hanspach, Gerd, Hengesbach, Martin, Tartaglia, Gian G, Vabulas, R Martin   +7 more
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]

, 2016
Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
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Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications [PDF]

, 2021
It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Garikipati, Venkata, Uchida, Shizuka
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A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]

, 2018
Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev, A Leibowitz, AA Ferrando, AA Smith, B Lecka-Czernik, C Fasolato, C Harteneck, C Morris, CL Hoppel, D Belelli, D Fietz, E Asmussen, E Chorell, E Pohjanen, G Lac, G Van Hall, GC Bogdanis, GD Lewis, GJ Rietjens, H Budde, H Budde, H Karlic, H Yokoyama, J Henriksson, JB Walker, JH Mitchell, JK Nicholson, JM Peake, JS Fuqua, K Goto, K Sahlin, K Sahlin, K Sato, K Sato, KR Howarth, LS Eriksson, ME Powers, MH Jacob, MH Williams, MJ Ormsbee, ML Circu, ML Goodwin, P Yin, PC Tullson, R Berton, RF Coburn, S Naz, SC Lu, SK Powers, TE Graham, W Dudzinska, YP Pitsiladis   +51 more
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tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
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