Results 41 to 50 of about 4,176 (133)

Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development [PDF]

, 2022
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell ...
Cao, Hongguo, Cao, Zhikun, Chang, Yuguang, Felici, Massimo De, Feng, Yanqin, Ge, Wei, Muhammad, Zafir, Shen, Wei, Wang, Jing, Yan, Zihui, Yi, Mingliang, Zhang, Zijun, Zhou, Tingting   +12 more
core   +1 more source

A lexicon of DNA modifications: their roles in embryo development and the germline [PDF]

, 2018
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes.
Amouroux, Aran, Arand, Arand, Aravind, Auclair, Bachman, Bachman, Bai, Bakhtari, Barrès, Basanta-Sanchez, Baubec, Bird, Bird, Bjelland, Blackburn, Booth, Borgel, Branco, Branco, Brasa, Breiling, Budzko, Canovas, Cao, Capuano, Cedar, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chistiakov, Choi, Church, Chuva de Sousa Lopes, Cimmino, Cortellino, Cortázar, Cui, Dai, Dawlaty, Dawlaty, Deplus, Dias, Ding, Dobbs, Donkin, Edwards, Eguizabal, Esanov, Esteller, Feng, Ficz, Ficz, Fidalgo, Fischer, Fleming, Forterre, Franklin, Frauer, Fu, Gabel, Gackowski, Gao, Gao, Gapp, Gapp, Gassen, Greer, Gross, Gu, Guenatri, Guo, Guo, Guo, Guo, Guo, Guo, Hackett, Hahn, Hainer, Han, Hardwick, Hargan-Calvopina, Hashimoto, He, He, He, Heras, Heyn, Hirasawa, Hnisz, Ho, Holland, Holliday, Holliday, Hon, Hon, Howell, Hu, Huang, Huang, Hudson, Huh, Hyldig, Ichiyanagi, Ideraabdullah, Inoue, Inoue, Iqbal, Ito, Ito, Ito, Iurlaro, Iurlaro, Iyer, Jafarpour, Jia, Jiang, Jones, Jurkowska, Kawasaki, Kellinger, Khoueiry, Kiani, Kim, Kinde, Klungland, Kobayashi, Kobayashi, Kobayashi, Kong, Koziol, Kweon, Laird, Law, Lee, Lee, Leenen, Lewis, Li, Li, Liang, Liao, Lin, Lister, Lister, Lister, Liu, Liu, Liu, Lu, Lu, Luo, Luo, López, Ma, Maatouk, Madrid, Magnani, Maiti, Marina, Masala, Maurano, Mayer, Mellén, Messer, Messerschmidt, Mondo, Monk, Mooijman, Nabel, Nakamura, Nakamura, Neri, Neri, Nestler, Nestor, Ngo, Ngo, Nilsson, Nordstrand, O'Brown, O'Neill, Okamoto, Okano, Olinski, Ooi, Oswald, Pan, Papale, Pastor, Patil, Peters, Petrussa, Petterson, Pfaffeneder, Pfaffeneder, Pfeifer, Piccolo, Pinney, Plongthongkum, Ponnaluri, Potok, Quenneville, Raiber, Ramsahoye, Rand, Rangam, Rasmussen, Ratnam, Reynolds, Rhoads, Riggs, Robertson, Robertson, Rodgers, Ronkainen, Rose, Ruzov, Sager, Salvaing, Sampath Kumar, Sarnacki, Sasaki, Schaefer, Schiffers, Schultz, Schuster, Seisenberger, Sharma, Shen, Shen, Shirane, Simpson, Skinner, Smith, Smith, Smith, Song, Song, Song, Sood, Sperlazza, Spruijt, Stadler, Strogantsev, Stroud, Stöger, Sun, Szulwach, Tan, Tang, Thakore, Thiaville, Tomizawa, Tseng, Tsukada, Tuorto, van Luenen, Vanyushin, Velasco, Vella, Vlachogiannis, von Meyenn, Vrachnis, Wahl, Wang, Wang, Wang, Wang, Wang, Watanabe, Watson, Williams, Wossidlo, Wu, Wu, Wu, Wu, Wu, Xu, Yamaguchi, Yamaguchi, Yamaguchi, Yang, Yildirim, Yu, Zaleski, Zeng, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu, Zhu, Ziller   +305 more
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Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty [PDF]

, 2021
Due to global aging, frailty and sarcopenia are increasing. Sarcopenia is defined as loss of volume and strength of skeletal muscle in elderlies, while frailty involves multiple domains of aging-related dysfunction, impaired cognition, hypomobility, and ...
Kameda, Masahiro, Kondoh, Hiroshi, Teruya, Takayuki, Yanagida, Mitsuhiro   +3 more
core   +1 more source

Emerging roles of RNA methylation in gastrointestinal cancers

Cancer Cell International, 2020
RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou, Xiaoyi Yan   +8 more
doaj   +1 more source

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

Frontiers in Pharmacology, 2021
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo, Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang   +10 more
doaj   +1 more source

Mapping epigenetic modifications by sequencing technologies [PDF]

, 2023
The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and
Chen, Xiufei, Shu, Xiao, Song, Chun-Xiao, Xu, Haiqi   +3 more
core   +2 more sources

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

The role of RNA modification in hepatocellular carcinoma

Frontiers in Pharmacology, 2022
Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng, Dongxu Wang, Tianyi Xue, Chao Lin, Yongjian Gao, Liqun Sun, Ye Jin, Dianfeng Liu   +7 more
doaj   +1 more source

Insights into the regulatory role of RNA methylation modifications in glioma

Journal of Translational Medicine, 2023
Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas.
Shengrong Long, Yu Yan, Hongyu Xu, Lesheng Wang, Jiazhi Jiang, Ziyue Xu, Runming Liu, Qiangqiang Zhou, Xiaopeng Huang, Jincao Chen, Zhiqiang Li, Wei Wei, Xiang Li   +12 more
doaj   +1 more source