Results 61 to 70 of about 4,176 (133)
The application of 'omics' to pulmonary arterial hypertension [PDF]
, 2020 Recent genome-wide analyses of rare and common sequence variations have brought greater clarity to the genetic architecture of pulmonary arterial hypertension and implicated novel genes in disease development.
Harbaum, L +4 more
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Frontiers in ImmunologyHepatocellular carcinoma (HCC) is a highly aggressive cancer with a poor prognosis. The molecular mechanisms underlying its development remain unclear.
Jin-Xiu Liu +3 more
doaj +1 more source
The epitranscriptome in stem cell biology and neural development
Neurobiology of Disease, 2020 The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences.
Caroline Vissers +3 more
doaj +1 more source
The biological function of demethylase ALKBH1 and its role in human diseases
HeliyonAlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong +4 more
doaj +1 more source
PLoS ONE, 2019 RNA contains various chemical modifications, among which N6-methyladenosine (m6A) is the most prevalent modified nucleotide in eukaryotic mRNA. Emerging evidence suggests that m6A plays an important role in regulating a variety of cellular functions by ...
Shun Matsuzawa +4 more
doaj +1 more source
Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5‐Formylcytosine Modification in Mitochondrial tRNA$^{Met}$ [PDF]
, 2017 Human mitochondria contain their own genome, which uses an unconventional genetic code. In addition to the standard AUG methionine codon, the single mitochondrial tRNA Methionine (mt‐tRNA$^{Met}$) also recognises AUA during translation initiation and ...
Minczuk, M, Powell, CA, Van Haute, L
core +2 more sources
SEX-SPECIFIC EFFECTS AND GENE-SEX INTERACTIONS IN SERUM METABOLOME LEVELS: THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY [PDF]
, 2018 Metabolomic signatures associated with complex disease have been identified. Metabolomic profiling and the integration of genomic data have proven to be powerful tools to investigate genetic effects underlying intermediate phenotype levels and may ...
Wang, Zhe
core +1 more source
Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications [PDF]
RNA molecules are not merely a combination of four bases of A, C, G, and U. Chemical modifications occur in almost all RNA species and play diverse roles in gene expression regulation. The abundant cellular RNAs, such as ribosomal RNA (rRNA) and transfer
Dai, Qing, He, Chuan, Zhang, Li-Sheng
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Frontiers in ImmunologyGlioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression.
Shao-Ze Zhang +6 more
doaj +1 more source
CHEMICAL SYNTHESIS AND BIOLOGICAL APPLICATION OF SENSITIVE RNA [PDF]
In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications ...
Apostle, Alexander T.
core +2 more sources